摘要
目的:探讨慢性牙周炎伴2型糖尿病患者血清RANKL和骨保护素(OPG)浓度变化与牙槽骨破坏的关系。方法:检查和分析健康组、牙周炎组、2型糖尿病组以及2型糖尿病伴牙周炎组患者血清RANKL和OPG的浓度、空腹血糖水平及牙周检查指数。结果:与健康组相比,牙周炎组OPG显著降低,RANKL略增高,RANKL/OPG比值增高(P<0.05);糖尿病组OPG明显增高,RANKL几无变化,RANKL/OPG比值降低(P<0.05);糖尿病伴牙周炎组OPG明显增高,RANKL略增高,RANKL/OPG比值降低;与牙周炎组相比,糖尿病组和糖尿病伴牙周炎组OPG明显增高,RANKL/OPG比值降低(P<0.05);空腹血糖与临床附着丧失,OPG浓度呈正相关,与RANKL/OPG比值呈负相关(P<0.05)。结论:糖尿病和牙周炎引起RANKL/OPG比值呈现不同的变化,提示糖尿病与牙周炎骨破坏机制可能不同,糖尿病患者与牙周病患者OPG浓度变化提示糖尿病患者的骨吸收可能还有未知的破骨机制。
Objective： To measure the serum levels of RANKL and osteoprotegerin（OPG） in patients of diabetes mellitus with or without periodontitis,and to explore the relationship between alveolar bone destruction and RANKL/OPG concentration.Methods： The levels of serum RANKL and OPG were compared among health（H）,periodontitis（P）,diabetes mellitus（DM） and DM＋P groups including blood test and periodontal examination.Results： In periodontitis group,OPG was significantly lower,RANKL was slightly increased,RANKL/OPG ratio was higher（P0.05）;in diabetes group,OPG was significantly higher（P0.05）,RANKL had almost no change,and RANKL/OPG ratio was decreased（P0.05）;in diabetes with periodontitis group,both RANKL and OPG were increased（P0.05）,but the ratio was reduced（P0.05）.In diabetes group and diabetes with periodontitis group,OPG was significantly higher（P0.05）,RANKL/OPG ratio was decreased compared to periodontitis group（P0.05）;fasting blood glucose was positively correlated to attachment loss and OPG levels（P0.05）,and negatively correlated to RANKL/OPG ratio.Conclusion： The cause of diabetes and periodontitis in the change of RANKL/OPG ratio was different;the changes of RANKL and OPG concentrations in diabetes and periodontal patients suggest unknown bone resorption mechanism.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2012年第6期770-774,共5页
Medical Journal of Wuhan University
基金
"十一五"国家科技支撑项目(编号:2007BAI18B02)
关键词
糖尿病
牙周炎
RANKL
骨保护素
Diabetes Mellitus
Periodontitis
RANKL
Osteoprotegerin
作者简介
曹玉林，女，1984-，医学硕士，主要从事牙周病治疗的研究
通信作者：李成章，男，1956～，医学博士，教授，主任医师，博士生导师，主要从事牙周病的宿主因素与引导牙周组织再生研究
