摘要
膜联蛋白A1/A2(annexins A1/A2,ANNXⅠ/Ⅱ)的膜聚集调节多种细胞的蛋白运输、细胞增殖和迁移,并与多条信号通路相关联,可能是肺动脉平滑肌细胞(pulmonary arterial smooth muscle cells,PASMCs)表型转换分子机制的关键变化,在肝源性肺血管重塑中发挥关键性调节作用。
The membrane aggregation of annexins A1/A2 regulates the protein transportation, proliferation and migration of various ceils, and is associated with multiple sigtml pathways. It may be a key change in the molecular mechanism of phenotype modu- lation in pulmonary arterial smooth muscle ceils and play a pivotal role in regulating hepatogenic pulmonary vascular remodeling.
出处
《医学研究生学报》
CAS
北大核心
2012年第10期1084-1087,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金(30700347
30872448
81170053
81170414)
关键词
膜联蛋白A1
A2
肺动脉平滑肌细胞
肝源性肺血管重塑
膜聚集
Annexins A1/A2
Pulmonary arterial smooth muscle cells
Hepatogenic pulmonary vascular remodeling
Mem-brane aggregation
作者简介
医学硕士研究生
通讯作者：易斌，E-mail：yibinl974@163．com
