摘要
目的评估1,5-脱水葡萄糖醇(1,5-AG)在初诊2型糖尿病(T2DM)患者血糖监测中的价值。方法选择初发T2DM患者192例,通过糖尿病教育、营养指导、调整口服药物或胰岛素剂量使血糖达标;比较治疗前和开始治疗后第2、4、8周患者的空腹静脉血糖(FPG),1,5-AG,果糖胺以及糖化血红蛋白(HbA1c)的变化。结果治疗2、4周时的1,5-AG为(5.40±2.81)μmol/L、(9.05±3.07)μmol/L,均明显高于治疗前的(1.86±1.30)μmol/L(P<0.05);HbA1c于治疗4周时开始下降。治疗8周时,血清1,5-AG与HbA1c、果糖胺、FPG水平呈负相关(r分别为-0.576、-0.594、-0.663,P<0.01)。结论 1,5-AG比HbA1c反应灵敏,能快速反应血糖变化,可用于T2DM患者早期的血糖监测。
Objective To evaluate the significance of monitoring serum 1,5- anhydroglucitol （1,5-AG） in newly diagnosed type 2 diabetes（T2DM）. Methods A total of 192 patients with newly diagnosed T2DM was treated with diabetes education, nutritional counseling and oral antihyperglycemic medications or insulin to keep blood glucose at a target level. Serum levels of 1,5- AG, HbAlc, fructosamine, and fasting plasma glucose（FPG） were monitored before and at 2,4 and 8 weeks during treatment. Results Serum levels of 1,5-AG at 2 and 4 weeks were （5.40 ± 2.81）μmol/L and （9.05 ± 3.07） μmol/L, respectively, which were higher than （1.86 ± 1.30） μmol/L before（P〈0. 05）. Serum HbAlc began to decrease at 4 weeks of therapy. At 8 weeks of therapy, the elevation of serum 1,5-AG was negatively correlated to the decrease of HbAlc, fructosamine and FPG （r=-0. 576,-0. 594 and -0. 663,P〈0. 01）. Conclusion Compared to HbAlc examination,detection of serum 1,5-AG is more sensitive in rapidly reflecting the changes of blood glucise and may be taken as an indicator for monitoring of T2DM patients in early stage.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第20期2418-2420,共3页
Jiangsu Medical Journal
作者简介
通讯作者：王尧E-mail：wang_yao100@163．com
