摘要
目的:探讨中青年2型糖尿病(T2DM)患者伴发勃起功能障碍(ED)与血管、神经和雄激素等因素的关系,为ED早期防治提供临床依据。方法:53例50岁以下男性T2DM患者按国际勃起功能指数-5(IIEF-5)评分分为ED组(IIEF评分≤21,n=28)和非ED组(NED组)(IIEF评分≥22,n=28),测定两组血脂、血糖、血清总睾酮(TT)、性激素结合蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-S)、计算法游离睾酮(cFT)等指标,检查两组视网膜病变(DR)、大血管病变和周围神经病变(DPN)等并发症,比较两组各指标及并发症的差异。结果:两组年龄、糖尿病病程、体重指数、血压、血脂、血糖水平具有可比性(P>0.05),ED组DR发生率(39.3%)高于NED组(4.0%)(P<0.05),两组TT、DHEA-S、cFT水平及大血管病变和DPN发生率差异均无统计学意义(P>0.05)。结论:T2DM患者伴ED发生与DR关系密切,对合并DR的T2DM患者尤应早期关注其勃起功能。
Objective： To investigate the relationship of erectile dysfunction（ED） with blood vessel-,nerve-and androgen-related factors in young and middle-aged men with type 2 diabetes mellitus（T2DM） in order to provide some clinical evidence for early prevention and treatment of ED.Methods： We divided 53 male T2DM patients under 50 years into an ED group（IIEF-5 score ≤21,n=28） and a non-ED（NED） group（IIEF-5 score ≥22,n=25）.We detected the levels of blood lipid,glucose,total testosterone（TT）,sex hormone-binding globulin（SHBG）,sulfate dehydroepiandrosterone（DHEA-S）,calculated free testosterone（cFT）,and examined the complications of macroangiopathy（MA）,diabetic retinopathy（DR） and diabetic peripheral neuropathy（DPN）,and compared the above indicators between the two groups.Results： There were no significant differences between the two groups in age,diabetes duration,body mass index,blood pressure,and blood lipid and glucose levels（P0.05）.The incidence rate of DR was significantly higher in the ED than in the NED group（39.3% vs 4.0%,P0.05）,but no statistically significant differences were found in the levels of TT,cFT,SHBG and DHEA-S and the incidence rates of MA and DPN between the two groups（P0.05）.Conclusion： The incidence of ED is closely related to DR in young and middle-aged men with T2DM.Therefore particular attention should be paid to the erectile function of T2DM patients with DR as early as possible.
出处
《中华男科学杂志》
CAS
CSCD
2012年第10期904-908,共5页
National Journal of Andrology
关键词
2型糖尿病
勃起功能障碍
视网膜病变
雄激素
type 2 diabetes mellitus
erectile dysfunction
diabetic retinopathy
androgen
作者简介
江小平（1966-），男，湖北武汉市人，主治医师，医学硕士，从事普通内科专业。Email：jbzh852@sohu．com
通讯作者：李芳萍，Email：amiy36@sohu．com
