摘要
目的研究金欣口服液不同极性部位的抗炎、祛痰和解热作用,筛选其治疗病毒性肺炎的药效部位。方法分别采用二甲苯致小鼠耳廓肿胀法、大鼠毛细管法排痰量和干酵母致热大鼠模型考察金欣口服液及其不同极性部位(石油醚、乙酸乙酯、正丁醇和水)的抗炎、祛痰和解热作用。结果与空白对照组比较,乙酸乙酯部位(P<0.05)和正丁醇部位(P<0.01)均有明显抑制二甲苯所致小鼠耳廓肿胀的作用;乙酸乙酯部位和正丁醇部位(P<0.01)均能显著增加大鼠毛细管排痰量;正丁醇部位对干酵母所致发热大鼠给药后1、2、3、4、5h均有显著降热作用(P<0.05或P<0.01)。结论乙酸乙酯部位和正丁醇部位是金欣口服液治疗病毒性肺炎的主要药效部位。
OBJECTIVE To study the anti-inflammatory, expectorant and antipyretic effects of different polar fractions of Jinxin Oral Liquid （JOL）, and then to screen the effective fractions treating viral pneumonia. METHODS Xylene-induced au- ricular swelling of mice, measuring the capillary expectorant quantity of rats and dried yeast suspension induced fever of rats was used to research the anti-inflammatory, expectorant and antipyretic effects of JOL and its different fractions such as petro- leum ether, ethyl acetate, n-butyl alcohol and water. RESULTS Compared with the blank control group, ethyl acetate extract and n-butyl alcohol extract significantly inhibited xylene-induced auricular swelling in mice （P〈0.05 and P〈0.0l respectively） ; they also remarkably increased the capillary expectorant quantity in rats （P〈0.01） ; n-butyl alcohol extract obviously re- duced the fever of rats induced by dried yeast suspension in 1 h, 2 h, 3 h, 4 h, 5 h respectively after it was taken （P〈0.05 or P〈0.05）. CONCLUSION Ethyl acetate and n-butyl alcohol are the dominant effective fractions of JOL treating viral pneumonia.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2012年第5期464-466,共3页
Journal of Nanjing University of Traditional Chinese Medicine
基金
高等学校博士学科点专项科研基金(20093237110006)
江苏省自然科学基金(BK2010560)
江苏省中医药科技项目(LZ11183)
江苏高校优势学科建设工程资助项目
关键词
金欣口服液
药效部位
抗炎
祛痰
解热
Jinxin Oral Liquid
effective fraction
anti-inflammatory
expectorant
antipyretic
作者简介
单进军（1979-），男，江苏大丰人，南京中医药大学助理研究员，博士。
通信作者：wscnj@126．com
