期刊文献+

2型糖尿病患者血清尿酸与真胰岛素和胰岛素原的关系 被引量:5

在线阅读 下载PDF
导出
摘要 目的研究2型糖尿病患者中血清尿酸(SUA)与真胰岛素(TI)、胰岛素原(PI)的关系。方法 79例受试者以SUA均值为界值分为两组,SUA高于均数组(B组)及低于均数组(A组)均行空腹糖耐量试验,空腹采血测定SUA、TI、PI及血脂(TC、TG、LDL-C、HDL-C、Apo-A1、Apo-B)、血糖、糖化血红蛋白(HbA1c),糖负荷后2 h采血测定血糖(2hPG)、TI(2hTI)、PI(2hPI),计算胰岛素敏感指数(ISI)和胰岛素抵抗指数(HOMA-IR),进行比较和分析。结果 B组男性较多,较肥胖,血压较高,TI、PI、2hTI、2hPI、TG、LDL-C、Apo-B高于A组,HDL-C、Apo-A1、低于A组I,SI降低,HOMA-IR升高,在B组,尿酸与TI、PI、HOMA-IR呈正相关,与ISI呈负相关,经多元logistic回归分析,TI、PI是尿酸升高的危险因素。结论 2型糖尿病血尿酸较高患者,更多伴有肥胖、血脂异常、血压升高,更具有高胰岛素血症、高胰岛素原血症及胰岛素抵抗倾向。
出处 《广东医学》 CAS CSCD 北大核心 2012年第17期2651-2654,共4页 Guangdong Medical Journal
  • 相关文献

参考文献16

  • 1COSTA A, IGUALA I, BOCTIM J, in subjects at risk of type 2 diabetes ponent of the metabolicsyndrome [ J ] 372 - 375. et al. Uric acid concentration mellitus: relationship to com- Metabolism, 2002, 51 (3) :372 -375.
  • 2CHIEN K L, CHEN M F, HSU H C, et al. Plasm uric acid and therisk of type 2 diabetes in a Chinese community [ J ]. Clin Chem, 2008, 54(2) : 310 -316.
  • 3李茂月,孙丽荣.2型糖尿病患者血清尿酸水平与尿酸排泄分数的相关性[J].天津医科大学学报,2009,15(1):121-124. 被引量:6
  • 4LEHTO S, NISKARMEN L, RORMEMAA T, et al. Serum uric acid is a strong predictor of stroke in patients with non - insulin - dependent diabetes mellitus [ J]. Stroke, 1998, 29 (3) : 635 - 639.
  • 5李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2126
  • 6朱宇,纪立农.2型糖尿病患者中高尿酸血症的研究[J].临床荟萃,2006,21(1):22-24. 被引量:41
  • 7CAPPUCCIO F P, STRAZZULLO P, FARINARO E, et al. Uric acid metabolism and tubular sodium handling results from a popu- lation-based study[J]. JAMA, 1993, 270(3) : 354 -359.
  • 8LEYVA F, WINGROVE C S, GODSLAND I F, et al. The glyco-lytic pathway to coronary heart disease: a hypothesis[ J]. Metabo- lism, 1998, 47(6) : 657 -662.
  • 9NISKANEN L, LAAKSONEN D E, LINDSTRON J, et al. Serum uric acid as aharbinger of metabolic outcome in subjects with im- paired glucosetolerance [ J ]. Diabetes Care, 2006, 29 (3) : 709 - 711.
  • 10CARNETHON M R, FORTMANN S P, PALANIAPPAN L, et al. Chambless, risk factors for progression to incident hyperinsuline- mia: The Atherosclerosis Risk in Communities Study, 1987 -1998 [J]. Am J Epidemiology, 2003, 158(11) : 1058 -1067.

二级参考文献22

  • 1马通军,冯凭.2型糖尿病伴高尿酸机制的研究进展[J].继续医学教育,2005,19(11):66-68. 被引量:12
  • 2刘晓梅,满安,甘文玉.2型糖尿病合并高尿酸血症对代谢的影响[J].广西医科大学学报,2006,23(1):92-94. 被引量:11
  • 3Bo S, Cavallo PP, Gentile L, et al. Hypouricemia and hyperuricemia in type 2 diabetes: two different phenotypes [J]. Eur J Clin Invest, 2001,31(4):318.
  • 4Daudon M, Traxer O, Conort P, et al. Type 2 diabetes increases the risk for uric acid stones[J]. Am Soc Nephrol, 2006,17(7): 2026.
  • 5Quaratino CP, Rucci C, Giacomello A. Relation between factional urate excretion and serum triglyceride concentrations[J]. Ann Rheum Dis,1996, 559(12):934.
  • 6Niskanen L, Laaksonen DE, Lindstron J, et al. Serum uric acid as a harbinger of metabolic outcome in subjects with impaired glucose tolerance[J]. Diabetes Care, 2006, 29(3):709.
  • 7Parvanova AI, Trevisan R, Iliev IP, et al.Insulin resistance and microalbuminuria: a cross-sectional, case-control study of 158 patients with type 2 diabetes and different degrees of urinary albumin excretion[J]. Diabetes, 2006, 55(5):1456.
  • 8Ghei M, Mihaileseu M, Levinson D. Pathogenesis of hyperuricemia: recent advances[J]. Curr Rheumatol Rep, 2002, 4(3):270.
  • 9Alderman M, Redfem JS. Serum uric acid-a cardiovascular risk factor[J]. Ther Umsch, 2004,61(9): 547.
  • 10Reaven GM. The kidney: an unwilling accomplice in syndrome X[J]. Am J Kidney Dis,1997,30(6) ,928-931.

共引文献2170

同被引文献54

引证文献5

二级引证文献29

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部