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脑转移联合胸部原发病灶切除治疗非小细胞肺癌 被引量:1

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摘要 目的:评估非小细胞肺癌合并孤立性脑转移患者接受外科治疗的有效性。方法:回顾分析本单位2001年至2011年间行脑部和胸部病灶联合切除的非小细胞肺癌孤立性脑转移患者临床及随访资料。结果:共计21例患者进行了孤立性脑转移病灶切除和后续的肺癌根治术,18例(86%)患者有纵隔淋巴结转移,其中N1淋巴结阳性8例,N2淋巴结阳性10例。中位生存期32个月(95%置信区间15~49个月),1年,2年和5年生存率分别为70%,43%,22%。对可能影响预后的指标进行单因素分析,提示淋巴结转移是影响预后的危险因素(P=0.002)。结论:对于非小细胞肺癌孤立性脑转移的患者,保证病灶完全切除和手术耐受性前提下,对胸部和脑部病灶应同时采取积极的外科治疗策略以获得最佳疗效。
出处 《实用医学杂志》 CAS 北大核心 2012年第18期3098-3099,共2页 The Journal of Practical Medicine
基金 广东省自然科学基金项目(编号:10451008901005515)
作者简介 通信作者:谷力加E-mail:jijil26@126.com
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  • 1Billing P S, Miller D L, Alien M S, et al. Surgical treatment of primary lung cancer with synchronous brain metastases [J]. J Thorac Cardiovasc Surg, 2001,122 (3) : 548-553.
  • 2Patehell R A, Tibbs P A, Walsh J W, et al. A randomized trial of surgery in the treatment of single metastases to the brain [J]. N Engl J Med, 1990,322(8):494-500.
  • 3Yano T, Ham A, Yoshida T, et al. Prognostic impact of local treatment against postoperative otigometastaes in non-smaU cell lung cancer [J]. J Surg Oncol, 2010, 102(7):852-855.
  • 4Mordant P, Arame A, De Domlnicis F, eta]. Which metastasis management allows long-term survived of synchronous so]itary Mlb non-small ceil lung cancer[J]? Eur J Cardiothorac Surg, 2012,41 (3) : 617-622.
  • 5黄玉娟,杨衿记,谢松喜,廖日强,吴一龙.第三代化疗方案联合放疗治疗非小细胞肺癌脑转移的探讨[J].实用医学杂志,2005,21(11):1192-1193. 被引量:3
  • 6Lo C K, Yu C H, Ma C C, et al. Surgical management of primary non-small-cell carcinoma of lung with synchronous solitary brain metastasis: local experience [J]. Hong Kong Med J, 2010, 16(3):186-191.
  • 7王希成,杨曙,王新宁,刘魁凤,庄承海.全脑放疗加伽玛刀治疗非小细胞肺癌多发脑转移的临床研究[J].实用医学杂志,2005,21(4):396-397. 被引量:7
  • 8Flannery T W, SuntharalingamM, Regine W F, et al. Long- term survival in patients with synchronous, solitary brain metastasis from non-small-cell lung cancer treated with radiosurgery [J]. Int J Radiat Oncol Biol Phys, 2008,72(1): 19-23.
  • 9Gore E M, Bae K, Wong S J, et al. Phase Ⅲ comparison of prophylactic cranial irradiation versus observation in patients with locally advanced non-small-cell lung cancer: primary ana/ysis of radiation therapy oneology group study RTOG 0214 [J]. J Clin Oncol, 2011,29(3) :272-278.
  • 10Scorsetti M, Alongi F, Navarria P, et al. Overall and disease- free survival greater than 12 years in metastatic non-small cell lung cancer after linear accelerator-based stereotactic radiosurgery for solitary brain metastasis [J]. Tumori, 2012, 98(2) : 31 e-34e.

二级参考文献10

  • 1Ohta Y, Oda M, Sunezuka Y, et al. Results of recent therapy for non- small cell lung cancer with brain metastasis as the initial relapse. Am J Clin Oncol, 2002, 25(5): 476-479.
  • 2杨学宁 吴一龙 见:吴一龙 主编.肺癌脑转移的多学科综合治疗[A].见:吴一龙,主编.肺癌多学科综合治疗的理论与时践[C].北京:人民卫生出版社,2002.245-262.
  • 3Robinet G,Thomas P, Bretan JL,et al. Results of a phase Ⅲ study of early versus delayed whole brain radiotherapy with concurrent cisplatin and vinorelbine combination in inoperable brain metastasis of non-small-cell lung cancer: Gmupe Franeais de Pneumo-Cancemlogie(GFPC) Protocol 95-1. Ann Oneo1,2001,12(1): 59 - 67.
  • 4孙燕 见:孙燕 主编.中枢神经系统肿瘤[A].见:孙燕,主编.肿瘤内科学[C].北京:人民卫生出版社,2001.493-505.
  • 5Rebatta P, Quantin X, Ardiet C, Morere JF, et al. Dose-finding ,pharmacokinetic and phase H study of docetaxel in combination with gemcitabine in patients with inoperable non-small cell lung cancer.Lung Cancer, 2001,33 (2-3) : 277 - 287.
  • 6Vokes EE, Leopold KA, Herndon J, et al. A randomized phase Ⅱ study of gemcitabine or paclitaxel or vinorebine with cisplatin as induction chemotherapy (Ind CT) and concomitant chemoradiotherapy (XRT)for unresectable stage Ⅲ non small cell lung cancer (NSCLC)(CALGB Study 9431) . Proc Annu Meet Am Soc Clin Oncol, 1999, 18(11):A1771.
  • 7Wolf M, Goerg C , Goerg K , et al. Carboplatin and simultaneous radiation in the treatment of stage ⅢA/B non-small cell lung cancer.Oncology, 1992,49(suppll 1 ) : 71.
  • 8Ball D , Bishop J , Smith J, et al. A phase Ⅲ study of accelerated radiotherapy with and without carboplatin in nonsmall ceB lung cancer :an interim toxicity analysis of the first 100 patients, lnt J Radiat Oncol Biol Phys, 1995,31 (2): 267.
  • 9赵森.转移性恶性肿瘤的治疗[A].见:汤钊猷.现代肿瘤学:第2版[C].上海:上海医科大学出版社,2000.542~543.
  • 10李彦和,郑立高,徐德生,康春生,刘东.脑转移瘤伽玛刀治疗[J].神经疾病与精神卫生,2003,3(1):43-45. 被引量:7

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