摘要
制备了trans-[RuCl4(DMSO)(4-EtPy)]Na·2DMSO(4-EtPy=4-乙基吡啶)(化合物1)和trans-[RuCl4(DMSO)(4-EtPy)][(4-EtPy)H](化合物2)。用UV、NMR研究了化合物在pH 7.40及5.00(0.15 mol·L-1NaCl,37℃)缓冲液中的水解机理-动力学和溶液稳定性。测得各水解反应表观速率常数、半衰期。研究结果表明:两个化合物的Ⅰ氯、Ⅱ氯及DMSO水解反应机理均与NAMI-A相似,但其各级水解速率比NAMI-A略快,即用4-EtPy取代咪唑环,可加快NAMI-A衍生物的Ⅰ氯、Ⅱ氯及DMSO水解反应速率。在含氮配体相同时,NAMI-A衍生物比相应NAMI衍生物的稳定性稍好。化合物在酸性溶液中的稳定性高于中性溶液。提供了用核磁法定量测定NAMI-A衍生物的水解机理-动力学。
trans-[RuC14（DMSO）（4-EtPy）]Na .2DMSO （4-EtPy=4-Ethyl pyridine） （compound 1） and trans[RuC14 （DMSO）（4-EtPy）][（4-EtPy）H] （compound 2） were synthesized. Their hydrolytic mechanismkinetics in pH 7.40/ 5.00 buffer solution and solution stabilities were studied by UV and NMR spectroscopy. Observed rate constant （kobs） and half-life time （t1/2） of the compounds were measured and calculated respectively. The result shows that the 1st and 2nd chloro-hydrolysis as well as DMSO-hydrolysis mechanisms for two compounds are very similar to that for NAMI-A. However, the measured hydrolytic rates of two compounds are somewhat faster than that of related NAMI-A, which means that replacing imidazole ring by 4-EtPy containing electron donating group would accelerate hydrolytic rate of NAMI-A derivatives. With the same nitrogen-donor ligand, NAMI-A derivative seems a little bit more stable than related NAMI derivative. The NMR method to quantitatively determine the mechanism-kinetics of NAMI-A derivatives was also provided.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2012年第10期2049-2058,共10页
Chinese Journal of Inorganic Chemistry
基金
澳门科技发展基金(No.012/2009/A1)
中国中医科学院基本科研业务费自主选题(No.ZZ03064,Z02089)资助项目
作者简介
通讯联系人:梁国刚。E-mail:Lguogang200@126.com
