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慢性心力衰竭病人外周血炎性因子和Th1/Th2细胞因子变化与心功能关系的临床研究 被引量:2

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摘要 目的观察慢性心力衰竭患者血清炎症因子及Th1/Th2细胞因子的改变,并探讨其与心功能的关系。方法将符合纳入标准的60例慢性心力衰竭患者和50例健康人分别设为观察组和对照组,采用ELISA法检测血清中C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的变化,ELISA法检测Th1/Th2细胞因子干扰素-γ(IFN-γ)和白介素-4(IL-4)的变化,并同步评估心功能指标。结果与健康人相比,心力衰竭患者血清中CRP、TNF-α和IL-6水平明显升高(P<0.05),与心功能的恶化呈正相关;心力衰竭患者Th1/Th2比值升高,升高程度与心功能恶化成正相关。结论心力衰竭患者外周血炎性因子水平上升,Th1/Th2细胞因子失衡,这两者皆与心功能密切相关。
作者 古锡钦
出处 《中外医疗》 2012年第24期45-46,共2页 China & Foreign Medical Treatment
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参考文献8

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