摘要
Toll样受体(TLRs)是一类Ⅰ型跨膜糖蛋白模式识别受体。至今在人类已发现11种TLRs,其可识别多种细胞内外病原体相关分子模式和损伤相关分子模式。活化的TLRs可激活转录因子,调节促炎性因子表达,参与固有免疫;启动和参与特异性免疫应答。TLRs分布广泛,多数TLRs在肾脏也有表达。TLRs信号通路介导多种感染性和非感染性肾脏疾病。调控TLRs信号通路有望成为治疗肾脏疾病的新手段。
Toll-like receptors（TLRs）,which belong to pattern recognition receptor,are type Ⅰ transmembrane glycoprotein.Until now,11 kinds of TLRs had been identified in human.TLRs participate in innate immunity through the activation of transcription factors which regulate the expression of pro-inflammatory cytokines and are required for the development of adaptive immune responses.The kidney constitutively expresses most TLRs.Overaction of TLRs contributes to the pathogenesis of many renal infectious and non-infectious conditions.Re-gulation of TLRs is a promising therapeutic way for renal disease.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2012年第17期1362-1365,共4页
Journal of Applied Clinical Pediatrics
基金
国家自然科学基金(30700775)
关键词
TOLL样受体
尿路感染
肾小球肾炎
急性肾损伤
肾移植排斥
Toll - like receptors
urinary tract intection
glomerulonephritis
acute kidney injury
kidney transplantation rejection
作者简介
作者简介：陶于洪，男，副主任医师，博士学位，硕士生导师，研究方向为肾小球疾病，电子信箱hxtyh@sina．com。
