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右美托咪定复合全麻对脊柱手术患者术中唤醒试验效果的影响 被引量:1

The Clinical Research of the Wake-up Test of Dexmedetomidine Combined Hoio-anesthesia
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摘要 目的探讨右美托咪定复合全麻对脊柱手术患者术中唤醒试验的影响.方法选取择期行脊柱手术患者40例,随机分为Ⅰ组和Ⅱ组,每组20例.两组均采用瑞芬太尼、阿曲库铵、异丙酚行麻醉诱导和麻醉维持,Ⅱ组患者麻醉诱导前即刻静脉推注右美托咪定1μg/kg,10min 注射完毕,然后以0.4μg/(kg? h)持续泵入;Ⅰ组(对照组)患者给予相同方法输注生理盐水.手术医师要求唤醒前20min 停止泵注丙泊酚及瑞芬太尼,将右美托咪定降至0.2μg/(kg? h),呼唤病人活动手足,之后静脉注射丙泊酚1mg/kg,麻醉维持同前.记录停药到患者自主呼吸恢复的时间(T1),自主呼吸恢复到手足运动的时间(T2),并评价唤醒试验的质量,同时记录麻醉前、诱导后、停药即刻、唤醒即刻、加深麻醉后10min 患者的 MAP,HR,BIS 的变化.结果Ⅰ组患者唤醒即刻的平均动脉压(MAP)、心率 HR)与停药即刻相比明显增高,差异有统计学意义(P 〈0.05);Ⅱ组患者唤醒即刻的 MAP,HR 与停药即刻相比无变化(P 〉0.05).两组唤醒时间差异无统计学意义(P 〉0.05).40例患者的唤醒试验质量均达到满意及以上标准.结论右美托咪定复合全麻对脊柱手术患者术中可实现安全快速的唤醒.
出处 《潍坊医学院学报》 2012年第4期269-271,共3页 Acta Academiae Medicinae Weifang
作者简介 徐加刚(1965年~),男(汉族),山东省诸城市人,副主任医师,学士学位。主要研究方向:临床麻醉学。
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