摘要
目的:比较瑞舒伐他汀与辛伐他汀对脑梗死患者颈动脉粥样斑块的影响。方法:选择我院脑梗死合并颈动脉粥样斑块的住院患者100例,按数字随机法均分为治疗组与对照组,治疗组在常规脑梗死基础治疗上,口服瑞舒伐他汀;对照组在常规脑梗死基础治疗上口服辛伐他汀。6个月后评定患者的血脂变化,并采用颈动脉超声观察患者颈动脉粥样硬化斑块内膜-中膜厚度(IMT)。结果:治疗后,2组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均显著降低(P<0.05),对照组的甘油三酯(TG)与治疗前比较无显著性差异(P>0.05),IMT厚度缩小程度较对照组显著(P<0.05)。2组均未见明显不良反应发生。结论:瑞舒伐他汀治疗脑梗死患者颈动脉斑块较辛伐他汀疗效显著,且安全性较好。
OBJECTIVE： To investigate the effects of rosuvastatin and simvastatin on carotid atherosclerotic plaques in patients with cerebral infarction. METHODS： 100 cerebral infarction inpatients with carotid atherosclerotic plaques were collected from our hospital, and they were randomized into treatment group and control group. On the basis of regular foundation treatment for cere- bral infarction, 50 cases in treatment group were additionally given rosuvastatin orally, and other 50 cases in control group given simvastatin orally. 6 months later, change of blood lipid was evaluated and carotid atherosclerosis plaques intima-media thickness （IMT） was observed by carotid ultrasound review. RESULTS： Total cholesterol （TC） and low density lipoprotein cholesterol （LDL-C） of 2 groups were decreased, and there was no statistical significance in TG of control group before and after treatment （P〉0.05）. The decrease of carotid plaques thickness in treatment group was more obvious than in control group, there was statisti- cal significance （P〈0.05）. CONCLUSION： Rosuvastatin is effective in the treatment of carotid atherosclerotic plaques in patients with cerebral infarction, and it is worthy of spreading in the clinic.
出处
《中国药房》
CAS
CSCD
2012年第36期3419-3420,共2页
China Pharmacy
关键词
瑞舒伐他汀
辛伐他汀
脑梗死
颈动脉粥样斑块
Rosuvastatin
Simvastatin
Cerebral infarction
Carotid atherosclerotic plaques
作者简介
副主任医师，本科。研究方向：脑血管病。电话：0594—2391806。E—mail：yaohuafan@yahoo．com．cn
