摘要
目的总结微小RNA(microRNA,miRNA)与胰腺癌之间关系的研究现状,探讨其表达谱在胰腺癌诊断中的重要作用。方法应用PubMed及CNKI期刊全文数据库检索系统,以"microRNA、胰腺癌"等为关键词,检索2000～2012年的相关文献,共检索到英文文献60篇和中文文献15篇。纳入标准为:miRNA与胰腺癌的基础与临床研究以及miRNA在胰腺癌诊治中的前景。根据纳入标准,纳入31篇文献。结果研究发现,miRNA表达谱如miR-21、miR-34、miR-217、miR-196a、miR-10a、miR-155、miR-221、miR-222、miR-181a、miR-181b、miR-181d、miR-200、let-7等家族成员可作为肿瘤标志物用于胰腺癌与正常胰腺、慢性胰腺炎、胰腺内分泌肿瘤等的诊断和鉴别诊断,预测胰腺癌的预后等。结论胰腺癌中miRNA的表达谱不但与胰腺癌的诊断相关,也为胰腺癌的基因治疗提供了新的研究方向和方法。
Objective To summarize the domestic and abroad articles related to the research on the relation between microRNA （miRNA） and pancreatic cancer, and explore the important effects of miRNA expression patterns in diagnosis of pancreatic cancer. Methods ＂microRNA and pancreatic cancer＂ were searched as key words by PubMed and CNKI series full-text database retrieval systems from 2000 to 2012. Totally 60 English papers and 15 Chinese papers were obtained. Choice criteria： the basic research of miRNA and pancreatic cancer, the clinical research of miRNA and pancreatic cancer, and the prospect of miRNA in pancreatic cancer diagnosis and treatment. According to the choice criteria, 31 papers were finally analyzed. Results The miRNA expression spectrum and specific miRNA expression such as miR-21, miR-34, miR-217, miR-196a, miR-10a, miR-155, miR-221, miR-222, miR-181a, miR-181b, miR-181d, and the family members of miR-200 and let-7 might be used as tumor markers to differentiate pancreatic cancer from normal pancreas, chronic pancreatitis or pancreatic endocrine tumors, and might be used as prognostic factor to predict the outcome. Conclusions miRNA expression spectrum are not only related to diagnosis of pancreatic cancer, but also have provided a new research direction and method for gene therapy of pancreatic cancer.
出处
《中国普外基础与临床杂志》
CAS
2012年第8期911-915,共5页
Chinese Journal of Bases and Clinics In General Surgery
作者简介
【作者简介】姚汝铖（1985年-），湖北省黄冈人，在读硕士，主要研究方向为肝癌、胰腺癌，E—mail：yaorucheng@163．com。
【通讯作者】郑军，E—mail：zhengjun1995@163．com
