摘要
目的探讨超声检查胎儿心脏异常与染色体异常的相关性。方法回顾性分析3307例产前检查时的胎儿心脏超声检查结果及染色体核型分析结果。分析心脏异常与染色体核型分析结果的相关性。结果在接受检查的3307例孕妇中，产前超声检查共有194例（5．87％）发现胎儿心脏异常征象，而3113例（94．13％）未发现胎儿心脏异常征象。染色体核型分析共有124例（3．75％）发现胎儿染色体核型异常。心脏异常者染色体异常发生率（19．59％，381194）明显高于无心脏异常者染色体异常发生率（2．76％，86／3113），其相对危险度为7．0903，差异有统计学意义（P〈0．01）。124例异常染色体核型中，以18-三体（42例）及21-三体（36例）最为常见。结论胎儿心脏异常者染色体异常发生率比较高，发现心脏异常征象时建议行染色体检查。
Objective To evaluate the correlation between ultrasound detected fetal heart abnormality and chromosomal abnormality. Methods The data of 3307 cases of prenatal fetal echocardiography and karyotype analysis results were retrospectively analyzed. The correlation between heart abnormality and chromosomal abnormality was analyzed. Results In 3307 cases of pregnant women, 194 cases （5.87%） were found signs of fetal heart abnormality,and 3113 cases （94.13%） were not found any sign of fetal heart abnormality. And 124 cases （3.75%） were found chromosomal abnormality. The rate of chromosomal abnormality in fetus with heart abnormality was higher than that in fetus without heart abnormality [ 19.59% （38/194） vs. 2.76% （ 86/3113 ）, P 〈 0.01 ], the relative risk ratio was 7.0903. One hundred and twenty-four cases of chromosomal abnormality in the 18-three-body （42 cases） and 21-three-body （36 cases） were the most common. Conclusions Fetal heart abnormality incidence of chromosomal abnormality is high relatively. When the signs of heart abnormality are found, it is suggested that the fetus should examine karyotype analysis.
出处
《中国医师进修杂志》
2012年第24期32-33,共2页
Chinese Journal of Postgraduates of Medicine
作者简介
通信作者：于金星，Email：yujinxing6210@163．com
