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甘精胰岛素联合瑞格列奈治疗2型糖尿病合并肾功能不全患者有效性和安全性 被引量:6

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摘要 糖尿病(DM)患者肾功能不全状态下,降糖药物在肾脏代谢和排泄延缓可导致药物在肾脏蓄积,可不同程度影响药物对机体血糖的控制效果并增加患者低血糖发生风险[1],多需给予胰岛素替代治疗,瑞格列奈口服92%经肝脏和胆道排泄,肾功能不全的患者可使用。本研究观察甘精胰岛素联合瑞格列奈治疗2型糖尿病合并肾功能不全患者的临床疗效和安全性。
出处 《中国临床保健杂志》 CAS 2012年第4期422-423,共2页 Chinese Journal of Clinical Healthcare
作者简介 作者简介:巩东坤,副主任医师,E—mail:904279877@qq.com
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  • 1黄晓程,贤晓丽.新型降糖药那格列奈的药理作用和临床应用[J].中国新药与临床杂志,2005,24(2):148-150. 被引量:29
  • 2卜石,邢小燕,王娜,赵文惠,杨文英.长效胰岛素联合口服降糖药治疗2型糖尿病的疗效与安全性[J].中国循证医学杂志,2004,4(7):464-467. 被引量:157
  • 3Ole Schmitz.长效胰岛素类似物的应用现状[J].国际内分泌代谢杂志,2006,26(3):197-198. 被引量:12
  • 4Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030[J]. Diabet Care, 2004, 27(5): 1047-53.
  • 5Halter JB, Kennedy L, Herman WH. Glycemic control and safety of insulin glargine in elderly patients with type 2 diabetes mellitus: the Goal Alc Study[J]. Diabetes, 2006, 55(Supple 1): A114.
  • 6Rosenstock J, Daily G, Massi-Benedetti M, et al. Reduced hypoglycemia risk with insulin glargine: a meta-analysis comparing insulin glargine with human NPH insulin in type 2 diabetes [J]. Diabetes Care, 2005, 28(4): 950-5.
  • 7YkiJarvinen H, Haring HU, Johnson E, et al. The relationship between glycemic control and hypoglycemia using insulin glargine versus NPH insulin: A meta regression analysis in type 2 diabetes [J]. Abstract, 2003, 52(suppl): A149-50.
  • 8Rosenstock J, Schwartz SL, Clark CM Jr, et al. Basal insulin therapy in type 2 diabetes: 28-week comparison of insulin glargine (HOE901) and NPN insulin[J]. Diabetes Care, 2001, 24(4): 631-6.
  • 9Blonde L,Merilainen M, Karwe V, et al, Patient-directed ti- tration for achieving glycaemic goals using a once-daily basal in- sulin analogue: an assessment of two different fasting plasma glucose targets-the TITRATETM study. Diabetes Obes Metab, 2009, 11: 623-631.
  • 10King AB. Once-daily insulin detemir is comparable to once-dai- ly insulin glargine in providing glycaemic control over 24 h in patients with type 2 diabetes: a double-blind, randomized, crossover study. Diabetes Obes Metab, 2009, 11:69-71.

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  • 1朱大龙,朱妍,李伟,王坚,刘超,胡文来,秦文浩,祁贯成,成兴波,郑立农.国产瑞格列奈治疗伴或不伴肾功能不全的2型糖尿病患者有效性和安全性的研究[J].中华糖尿病杂志(1006-6187),2005,13(5):381-382. 被引量:11
  • 2郑莜萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.143-150.
  • 3中华医学会糖尿病学分会_中国2型糖尿病防治指南(2010年版)[J].中国医学前沿杂志:电子版,2011,3(6):54-109.
  • 4Duran C, Tuncel E, Ersoy C, et al. The in- vestigation of the efficacy of insulin glar- gine on glycemic control when combined with either repaglinide or acarbose in ob- ese Type 2 diabetic patients[J]. Journal of Endocrinological Investigation, 2009,32 (1):69-73.
  • 5Namvaran F,Rahimi-Moghaddam P,Azarpira N. Polymorph-ism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population:relation with insulin" resistance and response to treatment with pioglitaz0ne in patients with type 2 diabetes mellitus[J].Molecular Biology Reports,2012(5):5511-5518.
  • 6Stephens JW, Bodvarsdottir TB,Wareham K. Effects of short- term therapy with glibenclamide and repaglinide on incretir hormones and oxidative damage associated with postprandial hyperglycaemia in people with type 2 diabetes mellitus [J] Diabetes Research and Clinical Practice,2011 (2): 199-206.
  • 7赵宏,辛中秋,姜海红.甘精胰岛素联合瑞格列奈治疗2型糖尿病的临床分析[J].医学信息,2015,2(12):155-156.
  • 8Jorge ML,de Oliveira VN,Resende NM. The effects of aero- bic,resistance,and combined exercise on metabolic control, inflammatory markers,adipocytokines,and muscle insulin sig-naling in patients with type 2 diabetes mellitus[J]. Metabolism- Clinical and Experimental, 2011(9):1244-1252.
  • 9杨爱萍.瑞格列奈治疗2型糖尿病的给药方式及临床效果观察[J].中国保健营养,2014,7(5下旬刊):140-141.
  • 10付文国.瑞格列奈治疗2型糖尿病的临床疗效与安全陛[J].中国保健营养,2014,24(2上旬刊):187-188.

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