摘要
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
The DNA damage response is critical for cells to maintain genome stability and survival.In this review,we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization.In addition,we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
基金
supported in part by grants from the National Institutes of Health,USA (No.R01CA133093 and R01ES016354)
the National Natural Science Foundation of China(No.81001027)
作者简介
Corresponding Authors： Su-Xia Han, Department of Radiation Oncology, First Affiliated Hospital, Xi＇an Jiaotong University, Xi＇an, Shaanxi 710061, P. R. China. Email： hansuxia2.2099@yahoo.com.cn.Corresponding Authors： Be Xu, Department of Radiation Oncology, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA. Tel： ＋1-713-441-3996; Fax： ＋1-713-441-4493; Email： bxu@tmhs.org.
