摘要
目的探讨18F-FDG PET/CT显像和血、胸水CA125检测对胸腔积液鉴别诊断的临床意义。方法 40例胸腔积液患者行18F-FDG PET/CT显像以及血、胸水CA125检测,结合最终病理诊断分组,评价其临床意义。结果血、胸水CA125检测结果在良恶性胸腔积液中不具有显著的统计学差异(P>0.05)。18F-FDG PET/CT显像对胸腔积液鉴别诊断的敏感性为92.3%,特异性为85.7%,ROC曲线下面积为0.890。血CA125检测敏感性为84.6%,特异性为28.6%,ROC曲线下面积为0.566。胸水CA125检测敏感性为100%,特异性为14.3%,ROC曲线下面积为0.571。三项联合检测ROC曲线下面积为0.890。结论18F-FDG PET/CT显像对于胸腔积液的鉴别诊断有较好的临床价值,血、胸水CA125检测不能单独用于胸腔积液鉴别诊断,且与前者联合并不能提高检测敏感性和特异性。
Objective To evaluate the clinical significance of 18F-FDG PET/CT imaging and detection of blood and pleural effusion CA125 in differential diagnosis of pleural effusion.Methods Forty patients with pleural effusion undergone 18F-FDG PET/CT imaging and blood and pleural effusion CA125 testing.Finally the clinical significance was evaluated by pathology diagnosis group.Results Blood and pleural effusion CA125 testing results were not significant in statistical difference between good and malignant pleural effusion（P〉0.05）.The sensitivity and specificity of 18F-FDG PET/CT imaging in differential diagnosis of pleural effusion and the area under the ROC curves were respectively 92.3%,85.7% and 0.890,while in blood CA125 testing respectively for 84.6%,28.6% and 0.566,and in the pleural effusion CA125 testing respectively for 100%,14.3% and 0.571.Three united detection area under the ROC curves are 0.890.Conclusions 18F-FDG PET/CT imaging for pleural effusion differential diagnosis has good clinical value.Blood and pleural effusion CA125 testing could not be used for the differential diagnosis,and theycombined with 18F-FDG PET/CT imaging can’t improve the detection sensitivity and specificity.
出处
《临床肺科杂志》
2012年第9期1656-1658,共3页
Journal of Clinical Pulmonary Medicine
作者简介
通讯作者：陈小东，E—mail：xdchen8@hotmail．com
