摘要
目的探讨标准型白细胞分化抗原(CD44s)的表达与慢性鼻-鼻窦炎(CRS)发病的关系。方法 30例CRS患者分为不伴鼻息肉的CRS(CRSsNP)16例(A组)和伴鼻息肉的CRS(CRSwNP)14例(B组),另取15例正常下鼻甲组织(C组)作为对照。对三组黏膜标本行HE染色,计数嗜酸性粒细胞。免疫组化染色(IHC法)测定CD44s的表达。对A、B两组患者,术前通过症状评分、内镜评分及CT评分评估其疾病严重程度。结果 B组术前内镜评分和CT评分以及术后病理检查嗜酸性粒细胞计数均明显高于A组(P<0.05)。CD44s主要表达于鼻窦病变黏膜及鼻息肉黏膜的上皮细胞、血管内皮细胞、基质炎症细胞和腺体上皮细胞;A、B组CD44s表达水平均明显高于C组(P<0.01),且B组比A组更显著(P<0.05)。CRS病变组织中CD44s表达水平与CT评分及嗜酸性粒细胞数目呈显著正相关(P<0.05)。结论 CD44s可能在CRS的发病机制中起重要作用,并可能与疾病的严重程度有关。
Objective To explore the role of CD44s expression in chronic rhinosinusitis（CRS）. Methods Thirty patients with CRS were grouped into two groups of A（16 cases, without nasal polyps） and B（14 cases, with nasal polyps）. Another 15 patients without CRS were taken as the controls（group C）. Disease severity was evaluated by symptom score, endoscopy score and CT score. The infiltrating eosinophils（Eos）in mucosa specimens were counted by HE stain and the expression of CD44s was detected by irnmunohistochemistry. Results Endoscopy score and CT score were significantly higher in group A than those in group B（P〈0. 05）. The number of tissues Eos was higher in group A than that in group B （P〈0. 05）. CD44s was mainly expressed in mucosa epithelial cells, vascular endothelial cells, submucosal gland cells and inflammatory cells within the subepithelial layer. CD44s levels were significantly higher in groups of A and B than those in group C（P〈0. 01）. CD44s expression was significantly higher in the group B than that in grouop A（P〈0. 05）. CD44s expression was positively correlated to CT scores and Eos infiltration（P〈0. 05）. Conclusion CD44s may play an important role in the pathogenesis of CRS and be associated with the severity of CRS.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第15期1768-1770,共3页
Jiangsu Medical Journal
作者简介
通讯作者：倪炳华E-mail：NTNbH@sina．com.
