摘要
目的调查2011年河南省某地一起丙型肝炎（丙肝）疫情的传染源及丙肝病毒（HCV）感染率。方法在疫情地区选取不同方位的5个村庄，共计5187名居民作为调查对象，通过问卷调查个人信息，每名对象抽取5ml血样检测抗-HCV，阳性者再采用Real—timePCR检测病毒核酸。结果5187名调查对象年龄1—97岁，平均48岁，男女比例为1：1．34。抗-HCV检测显示，HCV感染率平均为2．27％，其中1～9岁人群最低（1．55％），／〉50岁年龄组最高（4．93％）；各村之间感染率差异显著（0．55％～8．68％）。风险因素分析和距离与感染率线性回归分析表明，该次疫情可能与某诊所行医有相关性；多因素分析表明疫情主要传播途径为静脉注射、静脉滴注和内窥镜手术3种途径。结论该次HCV感染疫情为医源性感染。
Objective To describe the prevalence and risk factors of hepatitis C virus （HCV） occurred in Henan province, at the end of 2011. Methods Five villages round Maqiao township, including 5187 residents, were selected for the study. Five-milliliter-blood was drawn from every one of the interviewee. Clinical data including age, gender and anti-HCV antibody was recorded. Patients with positive antibodies against HCV were tested for HCV RNA. Results A total number of 5187 people from five villages were studied, with age span from 1 to 97. The average age was 48 years and the sex ratio was 1 ： 1.34. The anti-HCV result showed that the prevalence was 2.27%, with 1-9 age group the lowest （ 1.55% ） and the 〉/50 year-olds the highest （4.93%）. Different villages seemed to have significant differences on the prevalence of HCV, with the highest as 8.68% and the lowest as 0.55%. Under risk factors analysis and distance-infection rates linear regression analysis, data showed that the prevalence might have correlated to the behavior of a certain family-run clinic. Results from multivariate analysis indicated that factors as intravenous dropping, intravenous injection and the use of surgery/endoscope were associated with the HCV infection in this village. Conclusion Although the public health care system had been developed for more than ten years, iatrogenic infection was yet responsible for the infection of HCV patients in the rural areas of China that called for further attention paid to the system.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2012年第7期722-725,共4页
Chinese Journal of Epidemiology
关键词
丙型肝炎
疫情
风险因素
Hepatitis C
Epidemic
Risk factors
作者简介
通信作者：郭万申，Email：guows@hncdc．com．cn
