摘要
目的探讨糖尿病肾病患者血清同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的变化及其临床意义。方法将120例糖尿病患者分为单纯糖尿病组(DM组35例),早期糖尿病肾病组(DN1组41例),临床糖尿病肾病组(DN2组44例),另选健康体检者30例作为对照(对照组)。采用ELISA法分别测定各组患者血清Hcy、MMP-9、IL-6及TNF-α水平。结果糖尿病肾病患者血清中Hcy、MMP-9、IL-6及TNF-α水平高于对照组及DM组,DN2组血清中Hcy、MMP-9、IL-6及TNF-α水平高于DN1组,组间比较差异均有显著性(均P<0.05)。结论 Hcy、MMP-9、IL-6及TNF-α可能是糖尿病肾病发病机制中的炎症介质,在其发生发展过程中起重要作用。检测Hcy、MMP-9、IL-6及TNF-α有助于DN患者病情的判断。
Objective To investigate the changes of serum Hcy, MMP-9,IL-6 and TNF-α levels in pa- tients diabetic nephritis and the clinical significance. Methods 120 patients with type 2 diabetes were selected for this study. The patients were divided into three groups ： （ DM group 35 cases）, （41 patients with microalbu- minutia DNlgroup） and （44 patients with clinical protein DN2group）. 30 healthy subjects were used as control group. The serum levels of Hcy, MMP-9, IL-6 and TNF-α were measured with was measured enzyme linked im- munosorbent assay. Results Serum levels of Hcy, MMP-9, IL-6 and TNF-α were significantly higher in DN group than those in DM group and controls （ P 〈 0. 05 ）. Serum levels of Hcy, MMP-9, IL-6 and TNF-α were sig- nificantly higher in in group than those in DN1 group （P 〈 0. 05 ））. Conclusion Hcy, MMP-9, IL-6 and TNF- ot participated in the pathogenesis of diabetic nephropathy. Monitoring the changes of their serum levels was helpful for the management of the disease.
出处
《中国实用医药》
2012年第16期9-10,共2页
China Practical Medicine
