摘要
目的 探讨单独使用拉米夫定后引起应答不佳的原因，特别是酪氨酸-蛋氨酸-天门冬氨酸-天门冬氨酸（YMDD）变异的发生相关因素。方法 回顾性分析160例单独使用拉米夫定后出现应答不佳的病例，进行基线参数值、出现应答不佳时间、治疗中HBVDNA载量分析，分别研究它们与出现应答不佳的关系。结果 随着拉米夫定使用时间延长应答不佳的出现概率逐渐增加：12个月时变异率19.67%，36个月时达到49.18%（P＜0.05）。应答不佳的原因很多，YMDD变异只是较常见的一个。基线HBVDNA载量、ALT值与应答不佳出现率、YMDD变异率均有明确关系，分组比较，差异有统计学意义（P＜0.05）。结论 基线ALT水平越低、HBVDNA滴度越高，出现应答不佳和YMDD变异概率越大。
Objective To explore the use of lamivudine alone induced the poor response,especially the related factors of the occurrence of YMDD.Methods Retrospective analysis of 160 cases of the poor answering cases after lamivudine treatment,the baseline parameter values,the time appearing to the poor answering and the HBVDNA load in treatment were analyzed,to study their relationship with poor response.Results The lamivudine prolonged,the poor response to the probability gradually increase.The mutation rate in the 12nd month was 19.67% and in the 36th month was 49.18% （P〈0.05）.Response to the many reasons, the YMDD mutation is the more common one.The relationship among HBVDNA load, ALT level on baseline and the rate of poor response emergence,the YMDD mutation rate was clear.By comparison in groups,the difference was significant （P〈0.05）.Conclusion The lower baseline of ALT level,the higher of HBVDNA load,the greater probability of the poor response and the YMDD mutation.
出处
《中国基层医药》
CAS
2012年第12期1771-1773,共3页
Chinese Journal of Primary Medicine and Pharmacy
