摘要
褪黑素是松果体分泌的一种神经内分泌激素,在生物钟、生殖、免疫、抗氧化等方面有重要作用。褪黑素及其受体通过其主要的理化性质和生物学功能,对下丘脑-垂体-性腺轴发挥全线抑制作用。在不同年龄段抑制程度可能有所差别,其可能机制是下丘脑-垂体-性腺轴功能随年龄改变,对褪黑素的反应亦发生变化。研究褪黑素及其受体对下丘脑-垂体-性腺轴的作用,有利于发挥其在生物、医学、社会不同领域的优势。
Melatonin is a neuroendocrine hormone secreted by human′s pineal gland.which has an important influence on human′s biological clock,reproduction,immunity and antioxidation.Melatonin and its receptor function through their main physical and chemical properties with biological functions,and effect on hypothalamus-pituitary-gonadal axis,showing completely inhibition effect.The performance for different ages may vary in the degree of inhibition.The possible mechanism is that the hypothalamus-pituitary-gonadal axis function changes with age and the response to melatonin also changes accordingly.Studiesof the effect of melatonin and its receptor on hypothalamus-pituitary-gonadal axis function is beneficial to play its advantages in biological,medical,social and other fields.
出处
《医学综述》
2012年第11期1620-1623,共4页
Medical Recapitulate
基金
国家自然科学基金(30873283)
关键词
松果体/松果腺
褪黑素
褪黑素受体
下丘脑-垂体-性腺轴
抑制
Pineal body/pineal gland
Melatonin
Melatonin receptor
Hypothalamic-pituitary-gonadal axis
Inhibition
