摘要
目的:探讨血脂和血管内超声-虚拟组织(IVUS-VH)学评价急性冠脉综合征(ACS)和稳定性心绞痛(SA)患者冠状动脉粥样硬化斑块性质。方法:对44例ACS患者及22例SA患者行IVUS-VH分析,并对其血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白a[LP(a)]进行测定,计算LDL-C/HDL-C比值,分析冠状动脉粥样硬化斑块坏死核心(NC)所占的比例与LP(a)、LDL-C/HDL-C的相关关系。结果:ACS组斑块中NC和钙化组织比例明显高于SA组(t=4.669、9.894,P<0.001),而纤维组织及纤维脂肪组织则明显低于SA组(t=7.184、5.290,P<0.001)。ACS组患者血清LDL-C/HDL-C、LP(a)水平高于SA组患者(t=3.512、19.139,P<0.001)。ACS组患者冠状动脉粥样硬化斑块中NC比例与血清LP(a)水平有显著的相关性(r=0.549,P<0.001)。结论:LP(a)可能代替IVUS-VH帮助了解冠状动脉粥样硬化斑块的性质。
Aim：To investigate the correlation between blood lipid and intravascular ultrasound-virtual histology（IVUS-VH） in assessing characteristics of the coronary atherosclerotic plaques in patients with acute coronary syndrome（ACS） and stable angina（SA）.Methods：The coronary atherosclerotic plaques in 44 patients with ACS and 22 patients with SA were tested by IVUS-VH,and the serum levels of HDL-C,LDL-C and LP（a） were detected.The ratio of LDL-C/HDL-C was calculated.The correlation of the percentage of necrotic core and LP（a）,LDL-C/HDL-C was analyzed,respectively.Results：The percentages of necrotic core and dense calcium tissue in ACS were significantly higher than those in SA group（t=4.669,9.894,P0.001）,but the percentages of fibrous tissue and fibro-fatty tissue in ACS were significantly lower than those in SA group（t=7.184,5.290,P0.001）.There were obvious differences in serum level of LP（a） and the ratio of LDL-C/HDL-C between ACS group and SA group（t=3.512,19.139,P0.001）.There was a significant positive correlation between the percentage of necrotic core and serum level of LP（a）（r=0.549,P0.001）.Conclusion：LP（a） may be take the place of IVUS-VH to understand the characteristics of the coronary atherosclerotic plaques and guide the clinical practice.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2012年第3期396-398,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
血脂
血管内超声-虚拟组织学
斑块性质
blood lipid
intravascular ultrasound-virtual histology
characteristic of plaque
作者简介
通讯作者:李新华,男,1957年7月生,硕士,主任医师,研究方向:冠心病的诊治,E-mail:Lxinhua321@163.com
