摘要
目的:了解一贯煎加减辅助治疗慢性萎缩性胃炎的效果,及治疗后患者血清中白细胞介素-12(IL-12)和肿瘤坏死因子-α(TNF-α)的变化。方法:选择在我院确诊的慢性萎缩性胃炎患者,共86例,依患者入院顺序分为观察组(43)与对照组(43例)。观察组在常规治疗上加用一贯煎加减进行治疗,对照组应用常规性的治疗。观察二组治疗后的临床效果及对血清中IL-12和TNF-α的影响。结果:观察组患者的总有效率(95.35%)明显高于对照组(81.40%),治疗后观察组血清中IL-12和TNF-α的表达[(121.11±6.24),(36.72±10.76)ng.L-1]明显低于对照组[(31.21±7.73),(54.75±9.87)ng.L-1]。结论:一贯煎加减治疗慢性萎缩性胃炎的疗效明显,且能有效下调血清中IL-12和TNF-α的表达,从机体微环境中进行调节,临床治疗中可以应用。
Objective：To observe the curative effect,interleukin-12（IL-12） and tumor necrosis factor-α（TNF-α） change by Yiguanjian plusminus in patients chronic atrophic gastritis,for accumulating the clinical experience,directing the clinical work.Method：Eighty-six patients with chronic atrophic gastritis were divided into two groups.The control group（43 cases） were treated by routine treatment,the observation group（43 cases） were added Yiguanjian plusminus.We observated the efficacy and the change of IL-12 and TNF-α in two groups.Result：The total effective rate was obviously higher in the observation group than in the control group.The expressions of IL-12 and TNF-α were obviously lower in the observation group than in the control group after treatment.Conclusion：The Yiguanjian plusminus chinese medicine can improve the curative effect,regulate the expressions of IL-12 and TNF-α in patients with chronic atrophic gastritis,is worthy of being recommended in clinical treatment.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第11期248-250,共3页
Chinese Journal of Experimental Traditional Medical Formulae
作者简介
邱志洁，本科，副主任医师，从事消化泌尿系统疾病研究，0591—87557768，E—mail：876764589@qq．com
