摘要
目的评价利奈唑胺、去甲万古霉素(万古霉素)、替考拉宁治疗老年革兰阳性菌感染患者的临床疗效及安全性。方法回顾性调查老年下呼吸道革兰阳性菌感染患者55例,根据治疗方案,将患者分为3组:利奈唑胺组(11例,静脉用药,600 mg,2次/d,疗程10～14 d);去甲万古霉素组(18例,静脉用药,400 mg,3次/d,疗程7～14d);替考拉宁组(26例,静脉用药,首剂400 mg,维持剂量200 mg/d,疗程7～14 d)。比较分析各组治疗效果、药物毒副反应情况、平均住院天数。结果利奈唑胺组治疗有效率为81.8%(9/11),去甲万古霉素(万古霉素)组治疗有效率为55.6%(10/18),替考拉宁组治疗有效率为61.5%(16/26),各组间差异无统计学意义(P=0.345>0.05)。利奈唑胺组细菌转阴率为81.8%(9/11),盐酸去甲万古霉(万古霉素)素组细菌转阴率为72.5%(13/18),替考拉宁组细菌转阴率为77.4%(20/26),各组间差异无统计学意义(P=0.837>0.05)。3组患者治疗平均住院天数分别为(26.3±3.05)、(32.8±4.11)、(33.5±3.55)d,利奈唑胺组住院天数明显短于另外两组(P<0.05),万古霉素组和替考拉宁组平均住院天数间差异无统计学意义(P>0.05)。治疗过程中均未出现严重的不良反应。结论利奈唑胺、去甲万古霉素(万古霉素)、替考拉宁均是治疗老年下呼吸道革兰阳性菌感染患者的安全有效的药物,利奈唑胺可能有助于缩短患者疗程。
Objective To evaluate the efficacy and safety of linezolid,vancomycin hydrochloride and teicoplanin in elderly patients with lower respiratory tract Gram-positive bacterial infection.Methods The clinical data of 55 elderly patients with lower respiratory tract Gram-positive bacterial infection were retrospectively analyzed.Patients were treated with linezolid（600mg,linezolid,7-14d,n=11）,norvancomycin hydrochloride（400mg,3 times everyday,7-14d,n=18） or teicoplanin（first dose,400mg,maintenance dose 200mg,7-14d,n=26）.The clinical effect,adverse effect and median length of hospital stay of each group were analyzed.Results The clinical effective rates of linezolid,norvancomycin hydrochloride and teicoplanin groups were 81.8%（9/11）,55.6%（10/18）and 61.5%（16/26）,respectively（P=0.3450.05）.The bacterial clearance rates of three groups were 81.8%（9/11）,72.5%（13/18） and 77.4%（20/26）,respectively（P=0.8370.05）.The median length of hospital stay of three groups were（26.3±3.05）,（32.8±4.11） and（33.5±3.55）d;that of linezolid group was significantly shorter than those of other 2 groups.There were no obvious adverse effects detected in three groups.Conclusion Linezolid,norvancomycin hydrochloride,teicoplanin are all safe and effective antibiotics for elderly patients with lower respiratory tract Gram-positive bacterial infection.
出处
《同济大学学报（医学版）》
CAS
2012年第2期61-64,共4页
Journal of Tongji University(Medical Science)
关键词
下呼吸道感染
革兰阳性菌
老年
lower respiratory tract infection
Gram-positive bacterial
elderly
作者简介
吴先正（1962-），男，主任医师，硕士．E—mail：wuxianzheng1962@yahoo．com．cn
