摘要
目的报道一例系统性红斑狼疮(systemic lupus erythematosus,SLE)合并卡氏肺孢子菌肺炎(Pneumocystis pneumonia,PCP)的临床表现以及按照治疗指南对该例有磺胺过敏史的患者使用磺胺脱敏方案治疗的过程。方法参与我院重症监护病房收治的一例系统性红斑狼疮(systemic lupus erythematosus,SLE)合并卡氏肺孢子菌肺炎(Pneumocystis pneumonia,PCP),并有磺胺过敏史患者的治疗讨论,并对其临床资料进行回顾性分析。结果与结论此病例因磺胺药物过敏,采取抗感染并磺胺脱敏方法治疗后,症状缓解,痰涂片卡氏肺孢子菌肺炎阴性。通常认为感染是威胁自身免疫性疾病患者生命的主要原因,临床对于系统性红斑狼疮合并卡氏肺孢子菌肺炎采取综合性治疗是必要的措施。对于磺胺过敏而使用替代药物有禁忌证或疗效不理想的患者,建议参照治疗指南磺胺药物脱敏方案进行救治。
OBJECTIVE To report the clinical manifestations of one case systemic lupus erytilematosus （SLE） complicated with Pneumocystis pneumonia（ PCP）, and the process that in accordance with the treatment guidelines of the patients who had a history of sulfa allergy in patients with sulfa desensitization program treatment. METHODS Involved in the discussion of treatment of a patient in our hospitalg intensive care unit who has systemic lupus erythematosus（SLE） complicated with Pneumocystis pneumonia（PCP） and history of sulfur allergy, and analyze the clinical data of the patient retrospectively. RESULTS The middle-aged women suffering from systemic lupus erythematosus （systemic lupus erythematosus; SLE） combined Pneumocystis pneumonia （Pneumocystis pneumoni- a,PCP） infection. Due to her history of sulfa drug allergies, antibiotics and sulfa desensitization treatment were given. Symptoms were eased sputum smear PCP （negative）. CONCLUSION The infection is generally the main life-threatening reason to patients with au- toimmune disease in clinical, taking a comprehensive treatment is a necessary measure for patients with SLE combined PCP for the pa- tients who are allergic to Sulfa drugs with contraindications or undesirable effects using alternative drug. Desensitization treatment may be one of the choices for these patients.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2012年第9期728-730,共3页
Chinese Pharmaceutical Journal
关键词
系统性红斑狼疮
卡氏肺孢子菌肺炎
磺胺
脱敏治疗
systemic lupus erythematosus （SLE）
pneumocystis pneumonia（PCP）
sulfonamide
desensitization treatment
作者简介
冯雷，女，副主任药师研究方向：临床药学实践与合理用药监护
通讯作者：朱珠，女，研究员，教授研究方向：临床药学、临床药物动力学及药物安全性评价Tel：（010）65296513E-mail：zhuzhu666777888@yahoo．com．cn.
