摘要
目的:观察艾塞那肽(exenatide)对2型糖尿病患者临床疗效和胰岛β细胞功能的影响。方法:接受口服降糖药物治疗后不能有效控制血糖的2型糖尿病患者,在继续服用降糖药物的基础上,随机分组给予注射艾塞那肽或胰岛素治疗24周,治疗前及停药24 h后测定空腹血糖(FPG)、餐后2 h血糖(P2hPG)、HbA1C、体质量、空腹胰岛素(FINS)、胰岛素原(PI)、胰岛素原/胰岛素(PI/FINS)、胰岛β细胞功能指数(HOMA-β),同时在治疗过程中记录不良反应发生率。结果:艾塞那肽组治疗后与治疗前比较FPG、P2hPG、HbA1C、体质量、FINS、PI、PI/FINS、HOMA-β有统计学意义(P<0.05)。艾塞那肽组与胰岛素组比较,FPG、体质量、PI、PI/FINS、HOMA-β和胃肠道不良反应发生率具有统计学意义(P<0.05)。结论:艾塞那肽能降低糖尿病患者的FPG、P2hPG、HbA1C和体质量,并且改善胰岛β细胞功能,疗效与胰岛素比较,减轻体重和改善胰岛β细胞效果明显,降低P2hPG、HbA1c和减少低血糖发生率方面无明显优势,降低FPG效果不及胰岛素组,胃肠道反应较常见。
OBJECTIVE To evaluate the therapeutic efficacy and the effect on beta-cell function of exenatide treatment in type 2 diabetic patients.METHODS Type 2 diabetic patients who were not effctively controlled blood glucose after receiving oral hypoglycemic agents,on the basis of taking hypoglycemic drugs,were divided into exenatide group and insulin group.Before treatment,fasting blood glucose（FPG）,postprandial 2 h blood glucose（P2hPG）,glycosylated hemoglobin（HbA1C）,body weight changes,fasting insulin（FINS）,proinsulin（PI） concentration were determined.After 24 weeks follow-up,the above profiles were repeated 24h after cessation of medication.The incidence of hypoglycemia and gastrointestinal side effects during the treatment were recorded.RESULTS The levels of FPG,P2hPG,HbA1C,body weight,FINS,PI,PI/FINS、HOMA-β in exenatide group were significantly changed after treatment versus baseline（P〈0.05）.In exenatide group,FPG、body weight 、PI、PI/FINS、HOMA-βand the incidence of gastrointestinal side effects were significantly different（P〈0.05） compared with the insulin group.CONCLUSION Exenatide could improve the levels of FPG,P2hPG,HbA1C and body weight in diabetic patients.Compared with insulin,the effect of body weight reduction and the improvement of beta-cell function were in obvious.There was no obvious advantage to reduce the level of FPG,P2hPG,HbA1C and the incidence of hypoglycemia,but the gastrointestinal reactions were common.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2012年第9期723-725,共3页
Chinese Journal of Hospital Pharmacy
关键词
艾塞那肽
胰岛素
血糖
胰腺Β细胞
exenatide
insulin
blood glucose
pancreatic beta cells
作者简介
张文静，女，硕士，医师，电话：027—82211468，E-mail：zzzwjing@yahoo．com．cn
赵湜，女，硕士，主任医师，电话：027—82211474，Email：zhaoshiwuhan@126．com
