摘要
目的 探讨儿童精神分裂症可能的发病机制。方法 采用反向高效液相色谱法 ,测定16例儿童精神分裂症患儿 (患儿组 )和 11例患阑尾炎的患儿 (对照组 )脑脊液 (CSF)中谷氨酸、天门冬氨酸 (兴奋性氨基酸 )和甘氨酸 (抑制性氨基酸 )的浓度并进行比较。结果 患儿组CSF中谷氨酸为(9 7± 3 1) μmol L ,甘氨酸为 (9 1± 3 7) μmol L ,低于对照组 [分别为 (41 9± 2 2 3) μmol L和 (16 1±11 8) μmol L],而天门冬氨酸含量两组差异无显著性。 结论 儿童精神分裂症的发病机制中可能有氨基酸神经递质的参与。
Objective The purpose of this study was to understand the change of excitatory and inhibitory amino acid in cerebrospinal fluid (CSF) of children with schizophrenia Methods With reverse phase and high performance liquid chromatography (HPLC), the glutamic, glycine, aspartic acid were determined in CSF of 16 children with schizophrenia aged 11 14 years, and 11 controls aged 10 14 year with appendicitis Results The contents of glutamic [(9 7±3 1) μmol/L] and glycine [(9 1±3 7) μmol/L] were obviously lower than that of controls [(41 9±22 3) μmol/L and (16 1±11 8) μmol/L]; then there was no significant difference in aspartic acid between two groups Conclusion Amino acid neurotransmitters, may participate the pathology of childhood schizophrenia
出处
《中华精神科杂志》
CAS
CSCD
2000年第1期33-34,共2页
Chinese Journal of Psychiatry
