摘要
目的探讨生酮饮食对兔脊髓缺血再灌注损伤的影响。方法选用健康雄性兔45只,随机分为三组,A组行假手术,B组给予正常饮食(normal diet,ND)+缺血再灌注,C组生酮饮食(ketogenic diet,KD)6周后+缺血再灌注,B、C组结扎兔腹主动脉(A组只穿线不接扎)30 min后,再灌注48 h,观察三组神经功能评价、病理组织学观察神经元细胞,评价KD对兔心肌缺血再灌注损伤的保护作用。结果 A组神经功能评价、病理组织学观察神经元细胞正常。B组神经功能出现明显障碍,神经元细胞形态异常。C组神经功能障碍程度、神经元细胞形态异常较B组轻。结论用生酮饮食干预后脊髓缺血再灌注损伤减轻。
Objective To investigate the influence of Ketogenic diet on rabbit spinal cord ischemia-reperfusion injury.Methods 45 male rabbits were randomly divided into three groups,group A was given sham-operated,group B was given normal diet（normal diet,ND） ＋ ischemia-reperfusion,group C was given Ketogenic diet（Ketogenic diet,KD） after 6 weeks ＋ ischemia-reperfusion.B,C group were given ligation of rabbit abdominal aorta（A group weared tie line and was not connected） 30 minutes,then reperfusion 48 hours,the three groups of neurological evaluation were observed,the neurons was histologicaly observed,the protection of KD on myocardial ischemia-reperfusion injury in rats was evaluated.Results Group A of neurological evaluation,histological observation of neurons were both normal.The neurological of group B was significantly disordered,neuronal cell morphology was abnormal.The level of neurological dysfunction,abnormal neuronal cell morphology of group C were lighter than those of group B.Conclusion The ischemia-reperfusion injury reduces after the Ketogenic diet intervention.
出处
《中国医药导报》
CAS
2012年第11期31-32,共2页
China Medical Herald
关键词
生酮饮食
缺血再灌注损伤
兔
Ketogenic diet
Ischemia-reperfusion injury
Rabbit
