摘要
目的观察基序逆向诱导半胱氨酸丰富蛋白(reversion inducing cysteine rich protein with kazal motifs,RECK)及基质金属蛋白酶-9(matrix metalproteinase-9,MMP-9)在非小细胞肺癌(non-small-cell lung carcinoma,NSCLC)组织中的表达情况,探讨其表达与临床病理特征的关系。方法选取我院临床病理资料齐全的NSCLC标本66例,并选取30例炎性假瘤作为对照组。采用免疫组化法检测组织中RECK和MMP-9的表达情况,并进行统计学分析。结果RECK和MMP-9在NSCLC组织中的阳性表达率分别为40.9%和75.6%,与炎性假瘤对照组相比,两者差异均具有统计学意义(P<0.05)。RECK与MMP-9的表达与患者原发肿瘤大小,病理学类型,分化程度无关(P>0.05)。临床分期为Ⅰ～Ⅱ期组RECK阳性率高于Ⅲ～Ⅳ期(P<0.05),无淋巴结转组阳性率高于转移组(P<0.05),而MMP-9与之相反。NSCLC组织中RECK与MMP-9的表达呈负相关(P<0.05)。结论肺小细胞癌组织中RECK表达降低,MMP-9增高,两者联合检测有望成为评估临床预后的重要指标。
Objective To study the expression of RECK and MMP-9 in non-small-cell lung carcinoma （NSCLC） and analyze the clinical significance between RECK and MMP-9 expression. Methods 66 cases of NSCLS specimens and with complete clinical information were selected and 30 cases of inflammatory pseudotumor were used as control group. The expression of RECK and MMP-9 were detected by immunohistochemical method, then statistical analysis was performed. Results The positive rate of RECK and MMP-9 in NSCLC were 40.9% and 75.6%, repectively, they were significant difference compare with inflammatory pseudotumor group. There were no significant correlation was found with tumor size, pathological type and tumor differentiation （P 〉 0.05）. The positive rate of RECK in I - II stage was higher than III- IV stage, and the rate of lymph nodes metastases was higher than that without lymph nodes metastases （P 〈 0.05）, but it was opposite for MMP-9. The expression of RECK was negatively correlated with MMP-9 （P 〈 0.05）. Conclusion RECK is lowly expressed in NSCLC, and MMP-9 is upgraded. They may be served as an important marker for evaluation of clinical prognosis.
出处
《中国医药导报》
CAS
2012年第12期46-48,共3页
China Medical Herald
作者简介
通讯作者
