摘要
目的 优选茜草配方颗粒的提取工艺。方法 以干浸膏得率、大叶茜草素和羟基茜草素提取量为评价指标,采用正交试验设计法考察加水倍量、提取次数和提取时间3个因素对提取效果的影响,通过综合评分筛选出茜草的最佳提取工艺。结果 提取次数对试验结果有极显著影响,加水倍量对提取工艺的影响有显著意义,而提取时间对结果无显著影响。综合考虑各因素的影响及生产实际需要,确定的最佳提取工艺为:茜草饮片加入10倍量水,煎煮提取3次,每次1小时。结论 该工艺条件提取充分,稳定可行,对茜草配方颗粒的生产具有一定的指导和参考意义。
ObjectiveTo optimize the extraction process of Rubia cordifolia L.formula granule.MethodsExtraction yields of solid drug,rubimaillin and purpurin were regarded as investigation index,and the amount of water,extraction times and duration on extraction were evaluated by orthogonal experimental design,and the best extraction process was statistically analyzed and screened by multi-index comprehensive evaluation method.ResultsExtraction times had the most notable effect on experimental results,and the amount of water was the secondary notable effect on the results,while the duration of extraction had no notable effects.Considering the effects of three factors and actual production process synthetically,the optimum condition of extraction process was that the decoction pieces were decocted three times in 10 folds water,one hour each time.ConclusionThe optimum extraction process was simple,reasonable and stable,which will have some instruction meaning and reference value to the production of Rubia cordifolia L.formula granule.
出处
《环球中医药》
CAS
2012年第4期269-272,共4页
Global Traditional Chinese Medicine
基金
四川新绿色药业合作课题
关键词
茜草
配方颗粒
提取工艺
正交设计
大叶茜草素
羟基茜草素
Rubia cordifolia L.
Formula granule
Extraction process
Orthogonal design
Rubimaillin
Purpurin
作者简介
蔡乐（1983-），主管药师。研究方向：药剂学、医院药学。E—mml：caiel5009@163．com
通讯作者：刘萍（1953-），女，主任药师。研究方向：药剂学、临床药学。E—mail：liuping0707@yahoo．com．cn
