摘要
目的 比较一组黄种人和白种人正常和异常皮肤组织中褐黑素和优黑素含量。方法 采用高效液相色谱(HPLC)分析黄种人和白种人痣细胞痣、白种人发育不良性黑素细胞痣、恶性黑素瘤组织中优黑素和褐黑素含量。正常对照为痣周围皮肤组织。结果 黄种人正常皮肤和痣细胞痣组织中优黑素含量明显高于相应白种人皮肤组织 (P <0 .0 1,P <0 .0 5 ) ;而褐黑素含量则明显低于白种人皮肤组织 (P <0 .0 1,P <0 .0 1)。本文进一步显示在白种人发育不良性黑素细胞痣、恶性黑素瘤组织中褐黑素含量明显增高。
Objective to compare the levels of eumelanin and pheomelanin in nomal and abnormal skin between Chinese and Caucasion. Methods The study was performed with HPLC to analyse the content of eumelanin and pheomelanin in Chinese subjects with and Caucasion subjects with naevocytic naevu, dysplastic melanocytic nevi and malignant melanoma. Results It was shown that the eumelanin level from the tissues of Chinese normal skin and naevocytic naevu was significantly higher than that from the tissues of Caucasion (P<0.01,P<0.05),whereas the pheomelanin level from the tissues of Chinese normal skin and naevocytic naevu was significantly lower than that from the tissues of Caucasian (P<0.01,P<0.01). Patients with dysplastic melanocytic nevi and patients with melignant melanoma had remarkable higher pheomelanin contents in lesions. Conclusion It seems important to study on eumelanin and pheomelanin in melanogenesis further more.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2000年第3期149-150,共2页
The Chinese Journal of Dermatovenereology
基金
中华医学会皮肤病研究基金(诺华公司)资助
关键词
褪黑素
优黑素
皮肤痣
黑素瘤
高效液相色谱
Eumelanin Pheomelanin Naevocytic naevu Dysplastic melanocytic nevi Malignant melanoma High performance chromatography
