摘要
目的:比较七氟烷和丙泊酚对老年肺癌患者术后早期认知功能的影响。方法:80例65岁以上的老年肺癌患者择期行肺癌根治术,随机分为七氟烷组(S组,40例)和丙泊酚组(P组,40例),分别于术前1 d、术后6 h、1 d、3 d、7 d对患者进行简易智能精神状态评分(MMSE),并于麻醉前10 min、术毕10 min及术后1 d取血测定血清S100β蛋白。结果:两组患者年龄、体质量、手术时间和麻醉时间无显著性差异(P>0.05),术前MMSE评分及术前S100β蛋白亦无显著差异(P>0.05)。S组患者术后6 h、1d、3 d的MMSE评分均高于P组(P<0.05),术后7 d两组的MMSE评分无显著性差异(P>0.05)。与术前10 min相比,两组患者术毕10 min的S100β蛋白水平均明显升高(P<0.05),但两组间无明显差异(P>0.05),S组术后1 d的S100β蛋白水平低于P组(P<0.05)。结论:七氟烷与丙泊酚均可影响老年患者全身麻醉术后早期认知功能。但七氟烷与丙泊酚相比,术后认知功能障碍的发生率较低,恢复更快。
Objective： To compare the influence of sevoflurane and propfol anesthesia on the postoperative cognitive function in elder patients of lung cancer.Methods： 80 cases older than 65 years,patients of lung cancer,planned for selective radical resection of pulmonary carcinoma,were randomly divided into 2 groups,group S and group P（n=40）.Mini-mental state examination was conducted respectively at the time of 1d preoperative（pre-1 d）,6 h,1 d,3 d,7 d after the surgery.Blood samples were taken at the moment of 10 mins before induction（pre-10 min）,10 mins postoperative（post-10 min） and 1 d after surgery,for the detection of serum concentration of S100β protein.Results： In two groups,there was no significant difference of age,bodyweight,the time of anesthesia（P0.05）,the preoperative MMSE grade and the preoperative serum level of S100β.MMSE grade in group S at the moment of post-6 h,1 d and 3 d was higher than that in group P（P0.05）,but MMSE grade at post-7 d was not different significantly from each other group（P0.05）.Compared to the pre-10 mins,the levels of S100β of both groups at post-10 min increased significantly（P0.05）.There was no significant difference of S100β between the 2 groups at post-10 mins（P0.05）.And the level of S100β at post-1d in group S was lower than group P（P0.05）.Conclusion： Propofol and sevoflurane can affect the early cognitive function in elderly patients after anesthesia and surgery.Compared with propofol,sevoflurane shows lower incidence rate of postoperative cognitive dysfunction,and faster recovery.
出处
《天津医科大学学报》
2012年第1期102-105,共4页
Journal of Tianjin Medical University
作者简介
于学超（1978-）。男。主治医师。硕士在读，研究方向：临床麻醉、肿瘤麻醉；
通信作者：高鲁渤，E-mail：yuxuecha0333@yahoo．com．cn。
