摘要
动脉瘤性蛛网膜下腔出血后脑血管痉挛（cerebralvasospasm，CVS）的发生是一个多因素参与的过程，其发生机制复杂，临床表现和影像学检查结果并不一致。理论上，通过阻断钙通道、抑制Rho激酶、清除氧自由基和拮抗内皮素受体等措施能防治CVS，但各类药物的实际临床效果却不尽如人意，尤其是在改善临床转归方面。3H治疗的临床应用因存在诸多潜在并发症而受到限制，而动脉内介入治疗则受到技术、设备、适应证等因素的影响。因此，CVS的防治仍然面临着许多挑战。
The occurrence of cerebral vasospasm （CVS） following aneurysmal subarachnoid hemorrhage is a multi-factor participatory process. Its pathogenic mechanism is complex. The clinical presentation and imaging findings are not consistent. Theoretically, by the measures of blocking calcium channels, inhibiting Rho kinase, removing oxy gen flee radicals and antagonizing endothelin receptors and other measures can prevent and treat CVS, but the actual clinical effects of various drugs are not satisfactory, especially in the aspects of improving clinical outcomes. The clinical application of the 3H therapy has been limited because of having many potential complications, and the intra-arterial interventional treatment is limited by the technology equipment, indications, and other factors. Therefore, the prevention and treatment of CVS is still facing many challenges.
出处
《国际脑血管病杂志》
北大核心
2012年第3期198-203,共6页
International Journal of Cerebrovascular Diseases
关键词
血管痉挛
颅内
蛛网膜下腔出血
颅内动脉瘤
脑缺血
Vasospasm, Intracranial
Subarachnoid Hemorrhage
Intracranial Aneurysm
Brain Ischemia
作者简介
通信作者：柯开富，Email：kekaifu_nt@126．com
