摘要
目的:对比观察应用熊去氧胆酸(UDCA)辅助治疗婴儿胆汁淤积症的疗效及安全性。方法:回顾性分析62例婴儿胆汁淤积症患儿分为UDCA治疗组与常规保肝药对照组,比较两组治疗前后症状体征和肝生化指标的改善程度;并进一步在UDCA治疗组内对比应答欠佳者与疗效较好者,分析影响因素,并同时观察药物不良反应等情况。结果:UDCA组显效6例,有效21例,无效3例,总有效率为90.0%;对照组显效7例,有效19例,无效6例,总有效率为81.3%。两组治疗后肝功能生化指标均有下降,其中TBIL、AST、ALT治疗前后差异有统计学意义(P<0.05),而两组组间比较差异无统计学意义(P>0.05)。治疗观察期间两组均未见严重不良反应。结论:熊去氧胆酸联合内科综合治疗婴儿胆汁淤积症安全性良好,但与对照组相比未见明显疗效。应答欠佳组与较好应答组相比,因肝病相关临床症状明显就诊者、肝脏生物化学指标明显异常者及可疑代谢异常者可能对熊去氧胆酸的应答欠佳。
Objective：To evaluate the efficacy and safety of ursodeoxycholic acid in the treatment of Infantile cholestasis.Methods：A total of 62 patients with Infantile cholestasis were divided into the UDCA treatment group and the common hepatoprotective control group.Improvement of symptom signs and hepatic biochemical indicator were compared before and after the treatment,and the factors affecting the therapeutic responses of the UDCA were further analyzed by comparing the suboptimal biochemical responders with the good biochemical responders.Simultaneously,the adverse reaction was also observed.Results：There were 6 excellent,21 effective,and 3 ineffective in UDCA group,with a total effective rate of 90.0 %.There were 7 excellent,19 effective,and 6 ineffective in control group,with a total effective rate of 81.3 %.UDCA could significantly improve liver biochemistry.The decreases on total bilirubin,conjugated bilirubin and γ-glutamyl transferase in the treatment group were much higher than those in the control group（P0.05）.The side effect of two groups was mild in the whole process of treatment.Conclusion：Compared with conventional therapy,combined therapy with UDCA is more effective in improving the symptom and liver function of patients with cholestasis hepatic diseases,and UDCA has no evident side effect in such patients.Patients with obvious symptoms,marked abnormal liver tests and abnormal metabolism may have a suboptimal biochemical response to ursodeoxycholic acid treatment.
出处
《中国妇幼保健》
CAS
北大核心
2012年第11期1658-1660,共3页
Maternal and Child Health Care of China
关键词
肝病
胆汁淤积
熊去氧胆酸
Liver disease
Cholestasis
Ursodeoxycholic acid（UDCA）
作者简介
通讯作者
