摘要
目的:观察牙周基础治疗对2型糖尿病伴牙周炎(DMCP)患者血清中瘦素(leptin)的浓度、临床牙周状态、血糖控制的影响。方法:选取DMCP患者和不伴有全身系统性疾病的慢性牙周炎(CP)患者各30例进行牙周基础治疗。分别在治疗前、治疗后1个月和3个月记录所有患者牙周临床指数:探诊深度(PD),附着丧失(AL)及菌斑指数(PLI),并检测血清中糖化血红蛋白(HbA1c)及leptin的含量。结果:DMCP组中PD、PLI和血清leptin含量在治疗后1个月和3个月时均显著降低(P<0.05),AL和血清HbAlc含量仅在治疗后3个月显著降低(P<0.05)。CP组中PD和PLI在治疗后1个月和3个月时均显著降低(P<0.05),AL和血清leptin含量仅在治疗后3个月显著降低(P<0.05)。2组治疗前血清leptin含量与牙周临床指数呈正相关。结论:牙周基础治疗有助于DMCP患者的血糖控制、牙周状态改善和血清中leptin含量下降。
Objective： To study the effects of basic periodontal therapy on the serum leptin level and clinical periodontal measurements in type 2 diabetic patients with chronic periodontitis.Methods： 30 patients with type 2 diabetes and chronic periodontitis（DMCP） and 30 with chronic periodontitis（CP） were enrolled.All subjects received basic periodontal therapy.Probing depth（PD）,attachment loss（AL） and plaque index（PLI） were recorded at baseline,1 and 3 months after treatment.Glycated hemoglobin（HbA1c） and the concentration of serum leptin were measured.Results： At 1 and 3 months after treatment,PD,PLI and the concentration of serum leptin were significantly reduced（P0.05）in DMCP group,AL and the concentration of serum HbAlc reduced significantly 3 months after treatment（P0.05）.In CP group,PD and PLI significantly reduced（P0.05）1 and 3 months after treatment,AL and the concentration of serum leptin reduced significantly 3 months after treatment（P0.05）.The serum leptin level was correlated with clinical periodontal parameters before treatment in both groups.Conclusion： The basic periodontal therapy is effective in the control of blood glucose level,improvement of clinical periodontal parameters and decrease of serum leptin level in DMCP patients.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2012年第2期199-203,共5页
Journal of Practical Stomatology
基金
黑龙江省教育厅科学技术研究项目(编号:11521112)
关键词
牙周基础治疗
2型糖尿病
瘦素
糖化血红蛋白
Basic periodontal therapy
Type 2 diabetes
Leptin
Glycated hemoglobin A1c
作者简介
通讯作者：裴路0451—86605544E—mail：esy0411dl@163．com
