摘要
目的系统评价莫沙必利治疗胃食管反流病（GERD）的有效性和安全性。方法检索PubMed、EMBASE、OVID、维普咨询中国科技期刊数据库和万方数据资源系统，应用国际Cochrane协作网系统评价方法进行评价。结果共纳入21个试验（1666例），治疗组为莫沙必利加质子泵抑制剂（PPI）、对照组为单用PPI或PPI联合安慰剂。Meta分析显示，对于非糜烂性反流病，两组间疗效差异无统计学意义。莫沙必利5mg治疗糜烂性食管炎，治疗组和对照组间的4周食管炎治愈率差异无统计学意义（P=0．06），治疗组的4周症状缓解率优于对照组（P〈0．01），治疗组的6周食管炎治愈率优于对照组（P〈0．01），治疗组的6周症状缓解率优于对照组（P〈0．01），两组的8周食管炎治愈率差异无统计学意义（P=0．05），治疗组的8周症状缓解率优于对照组（P〈0．01）。莫沙必利10mg治疗糜烂性食管炎，治疗组的8周症状缓解率优于对照组（P=0．02）。结论就此21个试验行Meta分析，莫沙必利在治疗GERD方面具有良好效果和安全性，但由于纳入文献质量，应谨慎对待上述结论。
Objective To evaluate the efficacy and safety of mosapride in the treatment of gastroesophageal reflux disease （GERD）. Methods Papers of PubMed, EMBASE, OVID, VIP Database and WANGFANG Data were searched and reviewed according to international Cochrane Collaboration. Results A total of 21 trials （1666 patients） were included. The treatment group was with mosapride and PPI, the control group was with single PPI or PPI and placebo. The Results of Meta analysis showed： for non-erosive negative reflux disease, there was no significant difference in efficacy between two groups. As for erosive esophagitis treated with mosapride （Stag） ： There was no significant difference in the 4-week healing rates between treatment group and control group （P = 0.06）. The 4-week symptom relief rate of treatment group was better than that of control group （P~ 0.01）. The 6-week healing rate of treatment group was better than that of control group （P^0.01）. The 6-week symptom relief rate of treatment group was better than that of control group （P^0.01）. There was no significant difference in the 8-week healing rate of esophagitis between treatment group and control group （P= 0.05）. The 8-week symptom relief rate of treatment group was better than that of control group （P〈0.01）. For erosive esophagitis treated with mosapride 10rag, The 8-week symptom relief rate of treatment group was better than that of control group （P= 0.02）. Conclusion According to the meta-analysis of these 21 trails, mosapride was safe and effective in the treatment ofGERD. However due to the quality of the literatures, the above findings should be treated with caution.
出处
《中华消化杂志》
CAS
CSCD
北大核心
2012年第3期159-163,共5页
Chinese Journal of Digestion
作者简介
通信作者：陈胜良，Email：chenslmd@yahoo．com．cn
