摘要
目的观察持续静点硝普钠对扩张性心肌病难治性心力衰竭的疗效。方法选择扩张性心肌病充血性心力衰竭患者48例,在基础治疗(包括休息,限制钠盐摄入,给于利尿剂ACEI类药物及硝酸甘油静点和洋地黄等)3～5d无效的情况下改硝酸甘油为硝普钠持续静点,起始以0.1μg/(kg.min)泵入据血压下降或升高程度调整给药速度,观察心率,测定B型钠尿肽(BNP)水平及以超声心动图检查评估心脏收缩功能。结果 44例患者在治疗后心率均减慢且心衰症状均有明显改善,BNP水平明显降低,射血分数有所升高。结论硝普钠能够有效改善扩张性心肌病难治性心力衰竭患者血流动力学异常。
Objective To observe the efficacy of continuous intravenous infusion of sodium nitroprusside in treatment of cases of dilated cardiomyopathy with refractory heart failure.Methods Forty eight cases of dilated cardiomyopathy with congestive heart failure were treated with basic treatment including rest,limitation of sodium intake,application of diuretics,nitroglycerin and digitalis for 3 to 5 days,if it was invalid,then nitroglycerin would be changed to continuous infusion of sodium nitroprusside,starting with 0.1μg/kg/min by pump.The medication was adjusted according to the increase or decrease of blood pressure observed.The heart rate and serum level of brain natriuretic peptide（BNP） were measured,and assessment of systolic function by ultrasound echocardiography was carried out.Results Heart rate and symptoms of heart failure in 44 patients were significantly improved after treatment,their BNP level was significantly lowered and their ejection fraction was increased.Conclusion Sodium nitroprusside can effectively improve the hemodynamic abnormalities in cases of dilated cardiomyopathy with refractory heart failure.
出处
《临床和实验医学杂志》
2012年第6期419-420,共2页
Journal of Clinical and Experimental Medicine
关键词
扩张性心肌病
难治性心力衰竭
硝普钠
Dilated cardiomyopathy
Refractory congestived heart failure
Sodium nitroprusside
