摘要
目的观察金龙胶囊联合同期放化疗对非小细胞肺癌(NSCLC)的近期疗效及毒副作用。方法 64例局部晚期NSCLC患者,随机分为金龙胶囊联合放化疗治疗组32例,单纯放化疗治疗32例为对照组,放射治疗采用常规放疗,剂量5600～6000 cGy,同步化疗采用吉西他滨+顺铂(GP)方案化疗4周期。对照组采用单纯放化疗,治疗组采用同步放化疗联合金龙胶囊治疗。结果放化疗结束1个月,金龙胶囊治疗组患者的CR率和有效率(PR+CR)分别为16.7%、61.1%;对照组患者的CR率和有效率(PR+CR)分别为13.9%、58.3%,近期疗效无差异,治疗组生活质量明显提高,骨髓抑制、放射性肺损伤及放射性食管炎等放化疗毒副反应降低。结论金龙胶囊联合GP方案同步化放疗治疗中晚期肺癌,减轻了放化疗所致的毒副反应,生活质量改善明显,提高了中晚期肺癌的放化疗耐受性,值得在临床上大力推广应用。
Objective To evaluate the radiosensitivity and toxicity of Jin-Long Capsule combined with concurrent chemoradiotherapy for locally advanced non-small cell lung cancer（NSCLC）.Methods 64 patients with local advanced NSCLC were randomly divided into chemoradiotherapy group（n=32）and chemoradiotherapy plus Jin-Long Capsule group（n=32）.All the patients received radiotherapy and concurrent injection of GEM ＋ DDP regimen,radiotherapy was given with conventional fraction in 2Gy perfraction and five fractions per week.The total tumor doses were 56-60 Gy;In Jin-Long Capsule group,the patients Jin-Long Capsule.Results At the end of the therapy and 1month after the radiotherapy,the chemoradiotherapy plus Jin-Long Capsule group showed rate of Complete remission and Response rate were 16.7% and 61.1%,while the control group of patients,were 13.9% and 58.3%.there is no difference in short-term effect between the two groups;The treatment group significantly improved the quality of life,and reduce toxicity of bone marrow,radiation-induced lung injury and radiation esophagitis.Conclusion Jin-Long Capsule plus concurrent chemoradiotherapy reduce the chemoradiotherapy-induced toxicity,improve quality of life significantly and increase radiotherapy and chemotherapy tolerance in locally advanced non-small cell lung cancer.it is worth to promote the clinical application.
出处
《中国肿瘤临床与康复》
2011年第5期451-453,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
非小细胞肺癌
同步放化疗
金龙胶囊
Non-small cell lung cancer
Concurrent chemoradiotherapy
Jin-Long Capsule
作者简介
钟豪，女，主治医师，从事恶性肿瘤放化疗专业。
