摘要
目的优化雷公藤微乳透皮给药系统的处方。方法以累积透皮量及4 h炎症抑制率为评价指标,采用星点设计-效应面法,确定优化处方。结果优化处方中油相油酸比例为0.12、表面活性剂(Labrasol和磷脂)和助表面活性剂(乙醇和Pharmasolve)的比例为0.59,水相比例为0.29。这时微乳累积透皮量为35.87 mg/mL,4 h炎症抑制率为61.56%。结论使用星点设计-效应面法能够快捷便利地得到雷公藤微乳透皮给药系统的优化处方,且所建立的模型具有良好的预测性。
AIM To determine the optimal formulation of microemulsion transdermal drug delivery system（METDDS） of Tripteryglum wilfordii Hook.f.METHODS In light of the evaluation indexes of transdermal accumulation and 4 h inhibitory rate of inflammation,the formulation was ascertained by the central composite design-response surface methodology.RESULTS When the ratio of oleic acid as oil phase was 0.12,the ratio of surfactants（labrasol and phospholipid） and cosurfactants（alcohol and pharmasolve） was 0.59,and the ratio of water was 0.29,respectively.The transdermal accumulation was 35.87 mg/mL and the 4 h inhibitory rate of inflammation was 61.56%.CONCLUSION The optimal formulation of Tripteryglum wilfordii Hook.f.METDDS is obtained swiftly and simply by the central composite design-response surface methodology.The established model can lead to better prediction of this preparation.
出处
《中成药》
CAS
CSCD
北大核心
2012年第2期260-264,共5页
Chinese Traditional Patent Medicine
基金
上海市中药现代化项目(09dZ1971100)
上海市青年科技启明星项目(10QA1400800)
关键词
雷公藤
微乳透皮给药系统
星点设计-效应面法
Tripteryglum wilfordii Hook.f.
microemulsion transdermal drug delivery system（METDDS）
central composite design-response surface methodology
作者简介
王霄（1987-），男，硕士在读，药物新剂型与新技术。Tel：（021）51980071，E—mail：naturalconan@163．com
通信作者：沙先谊（1976-），男，副教授，药物新剂型与新技术。Tel：（021）5190073，E-mail：shaxy@futtan．edu．cn
