摘要
目的探讨GPX1基因Pro200Leu多态性与冠心病的关系。方法采用病例对照研究方法,收集早发冠心病患者375例,迟发冠心病患者519例,对照334人,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)基因分型技术对GPX1基因Pro200Leu多态性进行检测,采用logistic回归计算Pro200Leu多态性与冠心病风险的比值比(OR值)和95%可信区间(CI)。结果与对照组相比,早发冠心病组携带CT+TT基因型的个体比携带CC基因型更容易患冠心病,多因素调整后,OR=1.96(95%CI=1.17-3.31);迟发冠心病组与对照组相比较,多因素调整后则无统计学意义(OR=1.75,95%CI=0.76-4.02)。结论 GPX1基因Pro200Leu多态性T等位基因可能是早发冠心病的一个危险因素。
Objective To investigate the relationship between GPX1 gene Pro200Leu polymorphism and coronary artery disease （CAD）. Methods A hospital-based case-control study was conducted on 375 premature CAD, 519 late-onset CAD patients and 334 controls with polyrnerase chain reaction restriction fragment length polymorphism （PCR-RFLP） to detect the polymorphism. Logistic regression models were performed to estimate the odds ratios （ORs） with 95% confidence intervals （Cls）. Results The odds ratio of CT ＋ TT versus CC genotype of Pro200Leu polymorphisms with CAD between the early-onset CAD group and controls was statistically significant in the multiple logistic model （OR： 1.96, 95% CI： 1.17-3.31 ）. For the comparison between the late-onset CAD group and controls, the odds ratio became not significant after adjusting the potential confounders （ OR： 1.75,95 % CI： O. 76-4.02）. Conclusion The T allele of GPX1 gene Pro200Leu polymorphism may be a risk factor in early-onset CAD.
出处
《山东大学学报（医学版）》
CAS
北大核心
2012年第2期152-156,共5页
Journal of Shandong University:Health Sciences
基金
山东省自然科学基金资助项目(Y2007C005)
关键词
冠心病
GPX1基因
多态性
氧化应激
Coronary artery disease
Glutathione peroxidase 1 gene
Polymorphism
Oxidative stress
作者简介
杜训波（1986-），男，硕士研究生，主要从事心血管疾病流行病学的研究。
贾崇奇（1961-），男，教授，博士，主要从事心血管疾病流行病学的研究。Email：jiachongqi@sdu．edu．cn
