摘要
目的:探讨血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)水平与冠心病的关系。方法:检索并筛检2010年12月31日前发表的MCP-1水平与冠心病关系的相关文献,利用Rev Man 4.2对各项研究结果进行异质性分析,选择适当的分析模型进行Meta分析。结果:共纳入13篇文献,稳定型心绞痛(stable angina,SA)396例、不稳定型心绞痛(un-stable angina,UA)366例、急性心肌梗死(acute myocardial infarction,AMI)268例及正常对照446例。Meta分析结果显示,SA、UA及AMI组患者血清MCP-1水平明显高于正常对照组(P均<0.01)。SA组标准化均数差(standardized mean difference,SMD)=0.71,95%可信区间(confidential interval,CI):0.30～1.12;UA组SMD=1.98,95%CI:1.15～2.81;AMI组SMD=2.69,95%CI:1.67～3.70;UA组患者血清MCP-1水平较SA组患者高0.77～2.20倍标准差,AMI组较UA组患者高0.32～0.67倍标准差。结论:冠心病患者血清MCP-1水平明显升高,且MCP-1水平与冠心病的严重程度相关。
Objective： To evaluate the association between coronary heart disease（CHD） and serum concentration of monocyte chemoattractant protein-1（MCP-1）.Methods： CNKI,WanFang,VIP and PubMed databases were searched,and the end time was December 31,2010.Statistical analysis was performed with the software program review manage,version 4.2.Fixed-effects model and random-effects model were applied to process these data.Results： There were 13 clinical trials qualified under our selection criteria.The study included 396 stable angina（SA） patients,366 unstable angina（UA） patients,268 acute myocardial infarction（AMI） patients and 446 healthy control group.Meta-analysis showed that the standardized mean difference（SMD）of MCP-1 concentrations in the patients with SA was 0.71（95%CI：0.30～1.12）,SMD of UA group was 1.98（95%CI：1.15～2.81）,SMD of AMI group was 2.69（95%CI：1.67～3.70）.Each SMD of those three groups was higher than that of the healthy control group（P 0.01）.Moreover,serum MCP-1 concentrations in the patients with UA were 0.77 to 2.20 times of standard deviation higher than those in the patients with SA,and the concentrations of serum MCP-1 in the patients with AMI were 0.32 to 0.67 times of standard deviation higher compared to those in the patients with UA.Conclusion： High serum MCP-1 level is associated with the severity of CHD,while the precise relationship between serum MCP-1 concentration and CHD in Chinese population requires prospective study.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第1期136-140,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
科技部"十一五"课题(2008BAI57B04)
作者简介
通讯作者，E—mail：jie．wuyale@gmail．com
