摘要
功能失调性子宫出血(简称功血)是由于调节生殖的神经内分泌机制失常引起的异常子宫出血,而全身及内外生殖器官无器质性病变存在,其中50%发生于绝经过渡期。绝经过渡期功血的药物治疗效果差,部分患者因反复出血或严重贫血行子宫切除。近年研究发现,小剂量米非司酮治疗这一类型的功血效果良好,但其具体作用机制尚不十分清楚。现将米非司酮在绝经过渡期功血中的临床应用及其作用机制进行综述。
Dysfunctional uterine bleeding（DUB）is abnormal uterine bleeding caused by neuroendocrine system disorders.50% DUB occurred in the menopausal transition.Menopausal transition DUB has poor effects of drug treatment,some cases with severe anemia or recurrent bleeding had undergone hysterectomy.Studies found that Small dose of mifepristone worked well,but the specific mechanism is not yet clear.Here is to make a review on the mechanism of action of mifepristone and its clinical application in the menopausal transition DUB.
出处
《医学综述》
2012年第1期144-146,共3页
Medical Recapitulate
