摘要
为了比较自拟方芩连液和白虎汤对气分证动物模型的治疗效果,试验通过静脉注射内毒素(LPS)复制家兔气分证模型,并在2种药物治疗前后分别观察了家兔胃肠道黏膜组织的病理变化以及测定了血清免疫球蛋白(IgA)含量。结果表明:静脉注射LPS能致家兔胃肠道黏膜组织产生明显病理损伤,血清IgA含量上升;经白虎汤和芩连液治疗后胃肠道黏膜组织病理损伤显著减轻,但血清IgA含量仍然显著高于正常水平。说明白虎汤和芩连液对LPS引起的胃肠道黏膜组织损伤都具有显著的治愈效果,而对血清IgA的含量无显著影响。
To compare the efficacy of Qinlian Liquid with Baihu Soup on Qifen syndrome, LPS was injected intravenously to form a syndrome model in rabbit, and the pathologic observation in gastrointestinal mucosa tissue and serum IgA analysis were conducted before and after the treatment with the two kinds of formula respectively. The results showed that the lesions of rabbit gastrointestinal mucosa tissue were caused strikingly by LPS, and the level of serum IgA was increased. Then, after treated with Qinlian Liquid and Baihu Soup, the lesions were obvious- ly decreased, but the concentration of serum IgA was still in high level. The results indicate the two formulas can have obvious effects in treating the lesions of gastrointestinal mucosa tissue in rabbit with Qifen syndrome caused by LPS, while having no remarkable effect on the concentration of serum IgA.
出处
《黑龙江畜牧兽医》
CAS
北大核心
2012年第2期120-122,163,共4页
Heilongjiang Animal Science And veterinary Medicine
基金
"十一五"国家科技支撑计划项目(2008BADB4B01-2)
作者简介
张世栋（1983-），男，助理研究员，硕士，sdzhang2006@126．com．
通信作者：严作廷（1962-），男，副研究员，博士，yanzuoting@yahoo．com．cn．
