摘要
目的:比较2007年1月1日至2008年12月31日在浦东新区精神卫生中心门诊首次就诊的首发和慢性复发精神分裂症患者抗精神病药物治疗种类和剂量,分析其可能的影响因素。方法:采用自编的调查量表,将数据输入SPSS 11.5,采用参数及非参数统计方法进行分析。结果:共89例精神分裂症患者入组,首发组43例,复发组46例。35例(39.33%)患者合并苯二氮类镇静催眠药,36例(40.45%)患者接受抗精神病药物合并治疗,首发和复发组的差异均没有统计学意义(P>0.05)。非经典抗精神病药物的使用增加,较经典抗精神病药物的使用人数增多。复发组患者的药物治疗剂量(氯丙嗪当量)明显高于首发组,差别有统计学意义(P<0.05)。抗精神病药物合并治疗有统计学意义的影响因素为入组时BPRS评分,合并苯二氮类镇静催眠药物。结论:首发患者很少使用氯氮平治疗,慢性复发者的抗精神病药物治疗剂量比首发精神分裂症者高。
Objective：To study the demographic characters of first episode and relapse chronic schizophrenics who accepted their routine treatment in the clinics of Pudong Mental Health Centre from January 2007 to December 2008.Methods：All the patients were surveyed by the Self-edited Questionaire which included the general health state,diagnoses,career,family care,education etc.All the data were put in and analyzed with the software SPSS11.0.Results： Altogether forty-three first episode and forty-six relapse schizophrenia were agreed to take part in the program.Thirty-five（39.33%） schizophrenia patients were used with benzodiazepines,thirty-six（40.45%） schizophrenia patients were accepted more than two kinds of antipsychotics,there were no significant differences between the first episode and the relapse schizophrenia patients（P〉0.05）.The non-typical antipsychotics were used more frequently than the typical antipsychotics.The treatment dose of antipsychotics（chlorpromazine equivalent） is higher for the relapse than for the first episode schizophrenia patients,there were significant differences between them（P〈0.05）.Combined antipsychotics had relationships with the scores of BPRS（Brief Psychiatric Rating Scale） and the use of benzodiazepines.Conclusions： Clozapine had limited its use to first episode schizophrenia,and the treatment dose of antipsychotics was higher for relapse than first episode schizophrenia.
出处
《中国民康医学》
2012年第1期4-7,共4页
Medical Journal of Chinese People’s Health
基金
上海浦东新区卫生局科委资助(项目编号:PW2008A-19)
作者简介
通讯作者：秦虹云，E—mail：qinhongyun@sohu．com
