摘要
目的探讨女性人群晨尿中微量白蛋白／肌酐比值（UACR）与高血压及高血压前期的关联性。方法以苏州市金阊区1796名女性常住居民为研究对象，测量血压、身高、体重和腰嗣，调查生活习惯、疾病史等情况，检测血糖、血脂、血尿酸、尿微量白蛋白、尿肌酐，采用有序多分类logistic回归模型，进行UACR水平与血压水平的关联性分析。结果高血压、高血压前期、血压正常组的UACR水平分别为15．54（7．67～32．53）、9．01（5．45～18．06）、7．13（4．60～12．50）mg/g，UACR偏高率依次为27．57％、13．42％、9．61％，三组间的差异均有统计学意义（P〈0．05）。UACR水平处于1、2、3和4分位者，控制其他混杂因素后，其收缩压分别为125．3、128．8、130．8和135．11mmHg，舒张乐分别为80．9、82．7、84．0和85．9mmHg；发生高血压前期或高血压的危险性随着UACR水平的增加而升高，存在着剂量-反应关系；与最低分位者相比，调整了年龄、吸炯、饮酒、高血压家族史、超重、腹型肥胖、高血糖、血脂异常、高尿酸后，UACR水平处于第2、3、4分位者患高血压前期或高血压的危险性分别增加了0．32、0．72和1．37倍。结论女性人群中UACR水平与高血压和高血压前期相关联。
Objective This study was operated to investigate the association between urinary albumin-to-creatinine ratio （UACR） and physical situations as hypertension and prehypertension among women. Methods Blood pressure, height, weight and waist circumference were measured and factors such as cigarette smoking, alcohol intake, family history of hypertension, were investigated. Blood glucose and lipid, serum uric acid, urinary albumin and urinary creatinine were tested on 1796 women aged ≥ 30 years living in the Jinchang district of Suzhou. Associations between UACR and hypertension as well as prehypertension were analyzed, by using ordinal multinomial logistic regression models. Results The mean levels of UACR were 15.54 （7.67, 32.53） , 9.01 （ 5.45,18.06 ）, 7.13 （4.60, 12.50 ） mg/g and the rates of higher UACR were 27.57%, 13.42%, 9.61% in hypertensive, pre-hypertensive and normotensive subjects, respectively, with significant differences noticed among the three groups （P〈0.05）. The average systolic blood pressure/diastolic blood pressure appeared to be 125.3/80.9, 128.8/82.7, 130.8/84.0 and 135.1/85.9 mm Hg for participants with UACR in the first, second, third and fourth quartile, respectively. The risks of prehypertension or hypertension increased with increasing UACR levels. Dose-response relationship was seen between UACR and risks of prehypertension or hypertension. Multivariable adjusted odds ratios （95%CI） of prehypertension or hypertension in the upper quartiles of UACR were 1.32 （1.02, 1.70）, 1.72 （1.32, 2.24） , and 2.37 （1.80, 3.11 ） , respectively, when compared with the lowest quartile. Conclusion Elevated UACR was associated with both hypertension and prehypertension among women.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2012年第1期32-36,共5页
Chinese Journal of Epidemiology
基金
苏州市科技基金
作者简介
通信作者：张永红，Email：yhzhang@suda．edu．cn
