1Skjot RI., Oettinger T, Rosenkrands I, et al. Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immu- nodominant Teell antigens. Infect Immun, 2000, 68 (1):214-220.
2Pathak SK, Basu S, Basu KK, et al. Direct extracellular in teraction between the early secreted antigen ESAT-6 of Myco- bacterium tuberculosis and TLR2 inhibits TLR signaling in ma- crophages. Nat Immunol,2007,8(6):610-618.
3Harris J, De Haro SA, Master SS,et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuber- culosis, hnmunity,2007, 27(3):505-517.
5Derrick SC, Morris SL. The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of maerophages by activating caspase expression. Cell Microbiol, 2007,9(6):1547-1555.
6Brandt L, Elhay M, Rosenkrands I, et al. ESAT-6 subunit vaccination against Mycobacteriurn tuberculosis. Infect Immun, 2000,68(2) : 791-795.
7Langermans JA, Doherty TM, Vervenne RA, et al. Protec- tion of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6. Vaccine, 2005,23(21):2740-2750.
8McShane H, Brookes R, Gilbert SC,et al. Enhanced immuno- genicity of CD44 Tcell responses and protective efficacy of a DNA-modified vaecinia virus Ankara prime-boost vaccination regimen for routine tuberculosis. Infect Immun, 2001,69(2) : 681-686.
