摘要
目的分析高血压并糖尿病患者血清肿瘤坏死因子-α(TNF-α)水平与左心室舒张功能参数二尖瓣舒张早期峰值血流速度与二尖瓣环舒张早期峰值运动速度均值之比(E/Em值)相关性。方法入选正常对照组(A组)58例,单纯高血压患者(B组)66例,单纯2型糖尿病患者(C组)60例,高血压并2型糖尿病患者(D组)62例,用组织多普勒超声心动图测定四组左心室舒张功能参数E/Em值,并用酶联免疫吸附法测定各组血清TNF-α浓度。分别比较四组的E/Em值,血清TNF-α浓度,及两者的相关系数。结果 D组E/Em值,血清TNF-α浓度,及两者相关系数均高于A组、B组和C组,差异具有统计学意义。[E/Em值,D组:(11.4±3.9)比A组:(8.6±3.3)P<0.05,B组:(10.4±3.4)P<0.05,C组:(10.0±3.0)P<0.05],[血清TNF-α浓度,D组:(13.6±5.9)ng/L比A组:(7.2±2.0)ng/L P<0.05,B组:(10.9±5.0)ng/L P<0.05,C组:(10.3±4.1)ng/L P<0.05],[两者相关系数,D组:0.734比B组:0.643,C组:0.675〗。结论与单纯高血压和单纯2型糖尿病患者相比高血压并2型糖尿病患者血清TNF-α浓度和左心室舒张功能参数E/Em值明显升高,两者正相关性更强。
Objective To analyze the correlativity between serum tumor necrosis factor-α（TNF-α）and parameter of left ventricular diastolic function the ratio of mitral inflow velocity and mitral annular velocity in early period（E/Em）of patients with hypertension and diabetes mellitus.Methods Totally 58 persons in control group（A group）,66 patients with hypertension（B group）,60 patients with type 2 diabetes mellitus（C group） and 62 patients with hypertension and type 2 diabetes mellitus（D group）were chosen.Their parameters of left ventricular diastolic function（E/Em） were measured by ultrasonic cardiogram.And concentrations of serum TNF-α were determined by enzyme-linked immunosorbent assay.Four groups were separately compared the concentrations of serum TNF-α,the ratio of E/Em and correlativity between the two.Results The concentration of the ratio of E/Em,serum TNF-α,and correlativity between the two of D group were significantly higher than those of A,B,C groups.[E/Em,D group：（11.4±3.9） vs A group：（8.6±3.3）P0.05,B group：（10.4±3.4）P0.05,C group：（10.0±3.0）P0.05],[Concentration of serum TNF-α,D group：（13.6±5.9） ng/L vs A group：（7.2±2.0） ng/L P0.05,B group：（10.9±5.0） ng/L P0.05,C group：（10.3±4.1） ng/L P0.05],[Correlation,D group：0.734 vs B group：0.643 C group：0.675].Conclusions The parameter of left ventricular diastolic dysfunction（E/Em）,concentrations of serum TNF-α,and the correlativity between the two of the patients with hypertension and Type 2 diabetes mellitus are higher than those of the patients with Hypertension or Type 2 diabetes mellitus.
出处
《医药论坛杂志》
2011年第20期36-40,共5页
Journal of Medical Forum
关键词
高血压
糖尿病
肿瘤坏死因子
心脏功能
左
舒张性
Hypertension
Diabetes mellitus
Tumor Necrosis Factor
Cardiac function
Left
Diastolic
