摘要
通过控制反应物C60以及肌肽的量,合成了三种水溶性C60-肌肽衍生物。采用红外、紫外、核磁共振、元素分析等手段对其结构进行了表征;同时考察了它们对超氧阴离子自由基、羟基自由基的清除能力、还原能力及金属螯合能力。结果表明:随着反应物中肌肽含量的增多,制得C60-肌肽衍生物的抗氧化能力增强,这可能与-NH基的供电效应有关。
Three water-soluble carnosine C60 derivatives were synthesized by controlling the reaction ratio of C60 and carnosine. The products were characterized by FT-IR, UV, IH NMR and elemental analysis; meanwhile, theirs scavenging ability, reducing power and metallic chelating ability on free superoxide anion radical and free hydroxyl radical were studied. The results showed that the oxidation resistance of carnosine C60 derivatives increased with increasing carnosine content in reaction, which might relate to the electron donating effect of-NH groups.
出处
《湖南农业科学》
2011年第11期71-75,共5页
Hunan Agricultural Sciences
基金
上海市生物医药和农业科技领域重点科技项目(08391911500)
上海市优秀学科带头人计划(09XD1402000)
上海市教育委员会重点学科建设项目(J50704)
作者简介
孙涛（1970-），女，黑龙江依兰县人，副教授，博士，主要从事富勒烯衍生物的抗氧化性能研究。
通讯作者：周冬香
