摘要
[目的]观察疏降饮在治疗肝胃不和型反流性食管炎(RE)患者前后血浆中血管活性肠肽(vasoaetive intestional peptide,VIP)及胃动素(motilin,MTL)含量的变化,探讨VIP、MTL在RE中的发病机制及疏降饮治疗RE患者的可能作用机理。[方法]选择30例健康体检者,作为健康对照组;选择30例符合肝胃不和型RE诊断标准的患者,作为疏降饮治疗组,并在疏降饮治疗组治疗前、后根据症状分级量化标准进行评分;利用放射免疫分析(RIA)方法检测疏降饮治疗组治疗前、后和健康对照组血浆VIP、MTL含量。[结果]疏降饮治疗组治疗后、健康对照组分别与疏降饮治疗组治疗前比较,血中VIP明显降低(P<0.01)、MTL明显增高(P<0.05);疏降饮治疗组治疗后与治疗前比较,各主要症状积分及症状总积分均显著降低(P<0.01);疏降饮治疗组治疗肝胃不和型患者,临床症状愈显率(治愈率+显效率)为73.33%,总有效率达86.67%;胃镜愈显率(治愈率+显效率)达66.67%,总有效率达83.33%。[结论]肝胃不和型RE患者的发病与VIP含量的升高、血浆MTL含量的降低有关;调节VIP分泌减少、MTL分泌增加,从而促进胃肠运动、收缩食道下括约肌,防止胃、十二指肠内容物反流,可能是疏降饮治疗肝胃不和型RE的作用机制之一;疏降饮治疗肝胃不和型RE患者疗效可靠,并且无明显毒、副作用。
[Objective]To observe the changes of plasma lever of vasoaetive intestional peptide（VIP） and motilin（MTL） of patients who is incoordination between the liver and stomach of RE before and after the treatment of Shu Jiang Yin,to study the possible modern medicine mechanism of Shu Jiang Yin curing RE patients.To study the relationship of VIP,MTL and RE（Reflux Esophagits） and the clinical therapeutic effect of Shu Jiang Yin curing the RE patients of incoordination between the liver and stomach type.[Methods] 30 healthy subjects without any symptoms like RE were set up as normal control group;30 cases according with incoordination between the liver and stomach Type of RE diagnostic criteria were set up as Shu Jiang Yin treatment group,and to score before and after the treatment of Shu Jiang Yin according to symptom class and quantization standard.To get plasma of Shu Jiang Yin treatment group at prior-treatment and post-treatment and normal control group through colonoscope,measured with radionimmu-moassay method to determin the plasma VIP and MTL level.[Results]1.The plasma VIP level was lower（P0.01） and the plasma MTL level was higher（P0.05） in Shu Jiang Yin treatment group post-treatment than that in Shu Jiang Yin treatment group prior-treatment.2.Shu Jiang Yin treatment group prior-treatment＇s cardinal symptom integration and symptom integration together were significantly lower than post-treatment＇s（P0.01）.3.The clinical symptom healing rate of Shu Jiang Yin cured RE of incoordination between the liver and stomach type was 73.33%,and the total effective rate was 86.67%.The gastroscope healing rate was 66.67%,and the gastroscope total effective rate was 83.33%.[Conclusions] 1.The VIP level of RE of Dampness Stagnation due to incoordination between the liver and stomach type was obviously higher than healthy adult,but the MTL level was lower than health adult.2.To adjust VIP secrete reducing and MTL secrete increasing,for promoting gastrointestinal motility,contracting LES,preventing stomach and stomach refluxing may be one of the possible mechanisms of action of Shu Jiang Yin curing RE of incoordination between the liver and stomach type.3.Using Shu Jiang Yin to cure RE of incoordination between the liver and stomach type was proved to have reliable therapeutic effect and not have obvious poison or side effect.
出处
《浙江中医药大学学报》
CAS
2011年第4期498-500,503,共4页
Journal of Zhejiang Chinese Medical University
关键词
反流性食管炎
肝胃不和型
疏降饮
血管活性肠肽
胃动素
Reflux Esophagits
incoordination between the liver and stomach
Shu Jiang Yin
vasoaetive intestional peptide
motilin
